Staff Profile

Current Positions

Director of National Poisons Information Service (Newcastle) and UK Teratology Information Service, September 2019-

Consultant Physician and Clinical Toxicologist, Newcastle Hospitals NHS Foundation Trust, April 2009-

Honorary Clinical Senior Lecturer, Newcastle University, April 2009-

Honorary Consultant Clinical Toxicologist, UK Health Security Agency

‪Ruben Thanacoody‬ - ‪Google Scholar‬

Academic Qualifications and Professional Affiliations

MBBS 2nd Class Honours with Distinction, Newcastle University, UK, 1995

Doctor of Medicine (MD), Newcastle University, UK, 2005. Thesis: Factors affecting cardiac repolarisation in recipients of thioridazine. Supervisors: Prof S Thomas and Prof A Daly

Postgraduate Certificate in Medical Education, Newcastle University, 2016

Membership of Royal College of Physicians MRCP (UK), 1998   

Certificate of Completion of Specialist Training (CCST) in General Internal Medicine and Clinical Pharmacology, 2005

Fellow, Royal College of Physicians (Edinburgh), 2007

Fellow, Royal College of Physicians (London), 2013

Fellow, European Association of Poisons Centres and Clinical Toxicologists (EAPCCT), 2025

Member, British Pharmacology Society

Member, European Society of Medicine

Awards/Prizes

National Clinical Impact Award Level 1 2022-27

Wiley British Journal of Clinical Pharmacology Editors Performance Awards 2022 and 2025  

Esteem Indicators

Member British Pharmacopoeia Commission Herbal and Complementary Medicines Expert Advisory Group 2023-

External Examiner, Diploma/Masters in Medical Toxicology, Cardiff University 2023-

External Examiner, MSc in Experimental and Translational Therapeutics, Oxford University 2023-

External Clinical Adviser, Health Service Ombudsman 2021-

Executive Editor, British Journal of Clinical Pharmacology 2021-

Co-Editor Poisoning issue, Medicine 2020 and 2024

NPIS/Royal College of Pathologists/RCEM Lab Assay Working Group 2024

NPIS/Royal College of Emergency Medicine Antidote Guideline working group

Invited Member, Toxicology Specialist Interest Group, Royal College of Emergency Medicine 2024-

EAPCCT Member, Paracetamol (acetaminophen) poisoning clinical toxicology recommendations international collaborative group 2024-

Clinical Toxicology Expert Advisor to WHO to produce and update training material on laboratory investigation of chemical incidents and TPP Development Group for detection of diethylene glycol/ethylene glycol in contaminated medicines 2025 

Board member European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) 2022-2024

Clinical Lead, Yellow Card Centre (Northern & Yorkshire)

Medical Director, Regional Drugs and Therapeutics Centre, Newcastle-upon-Tyne 2019-2025

Member of MHRA ISAC (Independent Scientific and Advisory Committee) 2007-2014

Member of MHRA PEAG (Pharmacovigilance Expert Advisory Group) 2011- 2023

Member Paracetamol expert working group, European Medicines Agency 2017

Member MRCP UK Part 1 Standard-setting Group 2023-

Member MRCP UK Part 1 Specialty Question-Writing Group Clinical Pharmacology & Therapeutics 2007-2015

Member MRCP UK Part 1 Exam Board 2015-2022 

Chief External Examiner, Brighton & Sussex Medical School 2018-2022

Faculty of Medical Sciences Ethics Committee, Newcastle University 2010-2018

Invited Lectures at International Conferences/Congresses

EUSEM Congress, Vienna, Austria, October 2025. Novel benzodiazepines

Global Health Safety Initiative. Enhancing Public Health Management of Chemical Incidents through Collaboration with Poison Centres: a Case Studies Based Virtual Symposium Feb 2025. Shedding light on DNP poisoning in the UK: progress and challenges encountered.

MENATOX Congress, Feb 2025, Muscat, Oman. L-carnitine and carbapenem for valproic acid-induced toxicity.

APAMT Congress, November 2024, Penang, Malaysia. Novel benzodiazepines.

TAPNA Conference, May 2024, Melbourne, Australia. L-carnitine and meropenem for valproic acid overdose: uncovering the evidence?

TAPNA Conference, May 2024, Melbourne, Australia. Cobinamide and other novel cyanide antidotes.

MENATOX Congress, Feb 2024, Abu Dhabi, UAE. The SNAP protocol for paracetamol poisoning.

Belgium-Luxembourg Toxicology Society conference, October 2023, Oostduinkerke, Belgium. Paracetamol intoxication and the SNAP protocol.

EAPCCT International Congress, Palma, Mallorca May 2023. Acetaminophen in pregnancy: is it dangerous?

EUSEM Congress, Berlin, Germany October 2022. Paracetamol poisoning. Is SNAP the new black. How about fomepizole?

NACCT International Congress, Boston, US September 2016. Valproate overdose: what is the role of L-carnitine.

EAPCCT XXXVI International Congress, Madrid, Spain May 2016. Valproate overdose: what is the role of L-carnitine.

NACCT International Congress, Atlanta, US October 2013. Implications for acetylcysteine dosing regimen following results of the UK SNAP trial.

EAPCCT XXXIII International Congress, Copenhagen, Denmark May 2013. Clinical Toxicology of Ayurvedic Medicines.

EAPCCT XXXI International Congress, Dubrovnik, Croatia, May 2011.The pharmacology of drug delivery.

ESF EMRC Exploratory Workshop: Multidisciplinary consortium for the development of effective, but non-toxic drugs against MDRTB and XDR-TB. Lisbon, Portugal, 30 November – 4 December 2010. Clinical Trials using thioridazine for XDR-TB.

EAPCCT XXX International Congress, Bordeaux, May 2010. What is the evidence for Added benefit from Hemoperfusion? Con

EAPCCT XXVIII International Congress, Seville, May 2008. Clinical Toxicology of Ayurvedic Medicines.

Invited Lectures at National study days/congresses

RCEM Congress, October 2024, Gateshead. Guidelines in management of opioid overdose.

RCEM Congress, March 2023, London. Management of Digoxin Toxicity

RCEM Congress, March 2022, Bournemouth. What’s new in Emergency medicine toxicology?

RSM From COVID to Clinical Emergency Medicine Webinar, June 2022. Paracetamol overdose and the SNAP protocol

Current Teaching Contribution:

Strand Lead, MRes Translational Medicine and Therapeutics Programme

Module Leader, MRes Experimental Medicine and Therapeutics MMB8005

Lecturer, MRes Drug Discovery & Development MMB8006

Lecturer, BSc Pharmacology, Advanced Pharmacogenetics PED3005

Lecturer, BSc Pharmacology, Drug Discovery & Development PED3007

Previous Teaching contribution:

Course Director, Clinical Pharmacology & Therapeutics course, Stage 4 MBBS 2015-2020

Module Leader, Clinical Drug Development, MSc Clinical and Health Sciences, Newcastle University 2015-2017

Module Leader, Diploma in Therapeutics, Newcastle University, 2010-2013

Lecturer, Diploma in Clinical Research MCR8008

Lecturer, MRes Toxicology module MMB8032

Teaching projects contributor:

Development of a vertical Clinical Pharmacology & Therapeutics strand in the Newcastle University MBBS course using the British Pharmacological Society core curriculum for medical students

Development of key learning outcomes for Clinical Pharmacology & Therapeutics teaching in Europe as part of an Education Working Group of the European Association of Clinical Pharmacology &Therapeutics and its affilitated Network of Teachers in Pharmacotherapy (NOTIP)

Erasmus EU-funded project to develop a Diploma in Clinical Toxicology at Cairo University with Newcastle University and University of Malta as collaborators.

Global Public Health project funded by the Overseas Development Agency to train staff in low-income countries and provide assistance with poisons centre set up and development. I participated in 2 training missions in Addis Ababa, Ethiopia 2018 and Yangon, Myanmar 2020.

WikiTox, a web-based Clinical Toxicology Teaching Resource Project (http://curriculum.toxicology.wikispaces.net/) set up following a WHO workshop to develop and deliver a curriculum in clinical toxicology for low-income countries.

Esteem Indicators:

External Examiner, Diploma/Masters in Medical Toxicology, Cardiff University 2023-

External Examiner, MSc in Experimental and Translational Therapeutics, Oxford University 2023-

Member MRCP (UK) Part 1 Standard-setting Group 2023-

Member MRCP (UK) Part 1 Exam Board 2015-2022 

Member MRCP (UK) Part 1 Specialty Question-Writing Group Clinical Pharmacology & Therapeutics 2007-2015

Question Writer, BPS/MSC Prescribing Skills Assessment (PSA)

Chief External Examiner, MBBS, Therapeutics, Brighton & Sussex Medical School 2018-2022

National CPD Lead, UK National Poisons Information Service (NPIS) 2016-2020

Co-organiser, RCEM/NPIS Toxicology Study Days 2023, 2024

Research interests

1) Optimisation of antidote treatment for the management of poisoned patients

2) Pharmaco- and Toxico-vigilance

3) Epidemiology of poisoning

I led a national NPIS audit of antidote stocking in acute hospitals with showed huge variability in access to antidotes. This led to joint RCEM/NPIS guidelines on antidote availability for emergency departments in the UK and the setting up of 8 supra-regional antidote holding centres in England for category C rarely used antidotes.

I led a national study of patients treated with toxic alcohol poisoning, sponsored by EusaPharma, which showed that ethanol treatment caused more adverse reactions and medication errors compared to fomepizole. Fomepizole has been recommended as the first line treatment for toxic alcohol poisoning. Engagement with Waymade Pharmaceuticals has led to a marketing authorisation for fomepizole being granted by MHRA for treatment of ethylene glycol poisoning in the UK in 2024.

I have also served on advisory boards to SERB Pharmaceuticals and advised on dosing regimens for digoxin-specific antibodies for digoxin poisoning and indications for glucarpidase for methotrexate poisoning. I have published reviews on the optimal dosing of naloxone for opioid overdose and L-carnitine for valproic acid-induced toxicity.

I have also contributed to toxico-surveillance studies.

Paracetamol overdose

My research aims to optimise acetylcysteine treatment regimens for paracetamol poisoning to reduce adverse reactions without compromising efficacy. I devised using pharmacokinetic modelling a shorter 12h acetylcysteine regimen which was compared to the usual 21h regimen in the Scottish and Newcastle Anti-Emetic Pre-Treatment in Paracetamol Poisoning (SNAP) clinical trial. I was the Principal Investigator for the SNAP clinical trial in Newcastle 2010-2012. This showed the shorter 12h regimen of acetylcysteine reduced the incidence of vomiting and anaphylactoid reactions (Lancet 2013).

I subsequently devised a clinical SNAP protocol (Scottish and Newcastle Acetylcysteine protocol) which was endorsed by NPIS and implemented in clinical practice in several hospitals in the UK. An audit of effectiveness compared to the conventional 21h acetylcysteine regimen showed that the SNAP protocol was as effective as the conventional 21h protocol and was associated with fewer adverse reactions.(EClinical Medicine 2019).

In May 2023, the Royal College of Emergency Medicine (RCEM), National Poisons Information Service (NPIS) and British Association for the study of the Liver (BASL) issued a joint position statement recommending the SNAP regimen as the standard of care for treatment of paracetamol overdose in the UK.

I am currently involved in an international collaborative group looking to perform systematic reviews to provide consensus definitions and recommendations for the management of paracetamol overdose and chair of the HiSNAP Trial Steering Committee.

PhD supervision and examining

PhD supervisor, Newcastle University 2018-2022 (Amani Alrossies): Evaluation of a Shorter 12h Acetylcysteine Regimen & Development of a Simpler Acetylcysteine (SNAP) Protocol for the Treatment of Paracetamol Poisoning

PhD Progress Panel member and Internal Examiner Newcastle University: Emma Kampouraki, Jonathan Richardson, Salah Aboheilaika

PhD External Examiner: Ingrid Berling (University of Newcastle, Australia)

Contribution to national guidelines and reports

Royal College of Emergency Medicine and National Poisons Information Service Guideline for the Management of Patients with Suspected but Unidentified Poisoning in the Emergency Department. April 2025

Royal College of Emergency Medicine and National Poisons Information Service Guideline for the Assessment and Management of Acute Opioid Toxicity in Adults in the Emergency Department. April 2024

Royal College of Emergency Medicine and National Poisons Information Service Guideline on Antidote Availability for Emergency Departments September 2023.

RCEM, NPIS and BASL. Use of the SNAP Regimen for the Treatment of Paracetamol Toxicity in adults and children. May 2023

Thanacoody R, Waring WS, Good AM, Bateman DN, Lynch-Farmery R, O’Moore E. Burden of disease -Poisoning. Report commissioned by the Health Protection Agency Sept 2005

• Articles

  • Gray L, Beddard M, Jones S, Begum A, Azhar NB, Deslandes P, Coulson J, Bradberry S, Sandilands EA, Thanacoody RH, Ivory MO. Trends in tricyclic antidepressant prescribing and poisoning in England and Wales 2016-2020. British Journal of Clinical Pharmacology 2025, 91(6), 1727-1738.
  • Brooke N, Carter G, Jagpal P, Cook M, Jones S, Cole D, Harbon S, Donohoe E, Elamin M, Thanacoody R, Duarte-Davidson R. Toxicovigilance in the UK during the COVID-19 pandemic. Toxicology Research 2025, 14(6), tfaf177.
  • Williams H, Jagpal P, Sandilands E, Morrison E, Gray L, Thanacoody HKR, Beg E, Bradberry S, Ferner R. The problem of propranolol poisoning. British Journal of Clinical Pharmacology 2025, 91(11), 3114-3120.
  • Watt A, Caparrotta T, Bradberry S, Gray L, Thanacoody R, Jackson G, Sandilands EA. Poisoning in adolescents in the UK: a review of enquiries to the National Poisons Information Service. Archives of Diseases in Childhood 2025, 110(9), 687-692.
  • Chiew AL, Wood DM, Cao D, Overberg A, Faber K, Wong A, Thanacoody R, Pomerleau AC, Gosselin S, Bhalla A, Lonati D, Bateman DN. Paracetamol (acetaminophen) poisoning; consensus definitions of poisoning types and outcomes to be used in the clinical toxicology recommendations collaborative systematic review. Clinical Toxicology 2025, 63, 343-347.
  • Kazi B, Gray L, Thanacoody HKR, Pucci M, Tuthill D. Paediatric Colchicine Poisoning in the United Kingdom: A 10-Year Retrospective Case Series from the National Poisons Information Service. Archives of Diseases in Childhood 2025. In Press.
  • Humphries C, Clarke E, Eddleston M, Gillings M, Irvine S, Keating L, Miell A, Milne L, Muir L, O'Brien R, Oatey K, Raman R, Thanacoody R, Tuck S, Weir CJ, Wood DM, Dear JW. HiSNAP trial-a multicentre, randomised, open-label, blinded end point, safety and efficacy trial of conventional (300 mg/kg) versus higher doses of acetylcysteine (450 mg/kg and 600 mg/kg) in patients with paracetamol overdose in the UK: study protocol. BMJ Open 2025, 15, e097432.
  • Moyns E, Looms J, Jagpal PS, Day R, Sandilands EA, Gray LA, Thanacoody RHK, Bradberry SM. A review of cardiotoxic agent poisoning and the role of VA-ECMO as reported to the National Poisons Information Service (NPIS) 2018-2023. Toxicology Communications 2025, 9(1), 2524302.
  • Edwards EP, Gray LA, Elamin MEMO, Veiraiah A, Thanacoody RHK, Coulson JM. A case series of ibogaine toxicity reported to the United Kingdom National Poisons Information Service (NPIS) over a 10-year period. Clinical Toxicology 2025, 63(3), 212-216.
  • Edwards EP, Patel S, Gray LA, Veiraiah A, Bradberry SM, Thanacoody RHK, Coulson JM. A 10-year retrospective review of mushroom exposures reported to the United Kingdom National Poisons Information Service between 2013 and 2022. Clinical Toxicology 2025, 63(6), 426-433.
  • King A, Thanacoody R. Principles of assessment and diagnosis of the poisoned patient. Medicine 2024, 52(6), 330-333.
  • King A, Thanacoody R. Poisoning by antidepressants and antipsychotics. Medicine 2024, 52(6), 369-371.
  • Yard HE, Thompson JP, Gray L, Coulson JM, Bradberry SM, Sandilands E, Thanacoody R, Tuthill D. Paediatric opioid poisoning in the UK: a retrospective analysis of clinical enquiries to the National Poisons Information Service. Archives of Disease in Childhood 2024, 109, 894-897.
  • Vincent F, Thompson J, Gray L, Bradberry S, Sandilands E, Thanacoody R, Tuthill D. Medication errors involving intravenous paracetamol in children: experience from enquiries to the National Poisons Information Service. Archives of Disease in Childhood 2024, 109(7), 582-585.
  • Blundell M, Gill R, Thanacoody R, Humphries C, Wood DM, Dargan PI. Joint RCEM and NPIS best practice guideline: assessment and management of acute opioid toxicity in adults in the emergency department. Emergency Medicine Journal 2024, 41, 440-445.
  • Thanacoody R, Anderson M. Epidemiology of Poisoning. Medicine 2024, 52(6), 327-329.
  • Moyns EJ, Welby-Everard P, Karim NA, Thanacoody RHK. Treatment of chloramine-induced chemical pneumonitis with extracorporeal membrane oxygenation (ECMO) following bleach and disinfectant inhalation. Clinical Toxicology 2023, 61(2), 136-137.
  • Hughes BW, Gray LA, Bradberry SM, Sandilands EA, Thanacoody RH, Coulson JM. Metformin-associated lactic acidosis reported to the United Kingdom National Poisons Information Service (NPIS) between 2010 and 2019: a ten-year retrospective analysis. Clinical Toxicology 2023, 61(6), 445-452.
  • Thanacoody HKR. Large paracetamol overdose - Higher dose NAC is NOT required. British Journal of Clinical Pharmacology 2023, 89, 39-42.
  • Beaulieu J, Roberts DM, Gosselin S, Hoffman RS, Lavergne V, Hovda KE, Megarbane B, Lung D, Thanacoody R, Ghannoum M. Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review. Clinical Toxicology 2022, 60(7), 784-797.
  • Haden M, Wheatley N, Gray LA, Bradberry SM, Sandilands EA, Thanacoody RH, Coulson J. Potential cyanide poisoning reported to the UK national poisons information service: 2008–2019. Clinical Toxicology 2022, 60(9), 1051-1058.
  • Hondebrink L, Zammit M, Høgberg LCG, Hermanns-Clausen M, Lonati D, Faber K, Thanacoody R. Effect of the first wave of COVID-19 on Poison Control Centre activities in 21 European countries: an EAPCCT initiative. Clinical Toxicology 2022, 60(10), 1145-1155.
  • Gentile D, Adams R, Klatka M, Bradberry S, Gray L, Thanacoody R, Jackson G, Sandilands E. Carbon monoxide exposures reported to the UK National Poisons Information Service: a 4-year study. Journal of Public Health 2022, 44(3), 565-574.
  • Jagpal PS, Williams HA, Eddleston M, Lalloo D, Warrell D, Sandilands EA, Thanacoody R, Gray L, Bradberry SM. Bites by exotic snakes reported to the UK National Poisons Information Service 2009–2020. Clinical Toxicology 2022, 60(9), 1044-1050.
  • Lamb T, Stewart D, Warrell D, Lalloo D, Jagpal P, Jones D, Thanacoody R, Gray L, Eddleston M. Moderate-to-severe Vipera berus envenoming requiring ViperaTAb antivenom therapy in the UK. Clinical Toxicology 2021, 59(11), 992-1001.
  • Thanacoody R. Principles of assessment and diagnosis of the poisoned patient. Medicine 2020, 48(3), 156-159.
  • Pettie JM, Caparrotta TM, Hunter RW, EMorrison EE, David M Wood DM, Dargan PI, Thanacoody RH, Thomas SHL, Elamin MEMO, Francis B, Webb DJ, Sandilands EA, Eddleston M, Dear JW. Safety and Efficacy of the SNAP 12-hour Acetylcysteine Regimen for the Treatment of Paracetamol Overdose. EClinicalMedicine 2019, 11, 11-17.
  • Brinkman DJ, Tichelaar J, Mokkink LB, Christiaens T, Likic R, Maciulaitis R, Costa J, Sanz EJ, Maxwell SR, Richir MC, van Agtmael MA, EACPT and NOTIP. Education Working Group of the European Association for Clinical Pharmacology and Therapeutics (EACPT)and its affiliated Network of Teachers in Pharmacotherapy(NOTIP).Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study. Clinical Pharmacology & Therapeutics 2019, 104(2), 317-325.
  • Bailey GP, Rehman B, Wind K, Wood DM, Thanacoody R, Nash S, Archer JRH, Eddleston M, Thompson JP, Vale JA, Thomas SHL, Dargan PI. Taking stock: UK national antidote availability increasing, but further improvements are required. European Journal of Hospital Pharmacy 2016, 23(3), 145-150.
  • Thanacoody HKR. Serotonin syndrome. Medicine 2016, 44(2), 95-96.
  • Thanacoody HKR. Quinine and chloroquine. Medicine 2016, 44(3), 197-198.
  • Thanacoody HKR, Gilfillan C, Bradberry SM, Davies J, Jackson G, Vale JA, Thompson JP, Eddleston M, Thomas SHL. Management of poisoning with ethylene glycol and methanol in the UK: a prospective study conducted by the National Poisons Information Service (NPIS). Clinical Toxicology 2016, 54(2), 134-140.
  • Thanacoody R, Caravati EM, Troutman WG, Hojer J, Benson BE, Hoppu K, Erdman A, Bedry R, Megarbane B. Position paper update: Whole bowel irrigation for gastrointestinal decontamination of overdose patients. Clinical Toxicology 2015, 53(1), 5-12.
  • Kamour A, George N, Gwynette D, Cooper G, Lupton D, Eddleston M, Thompson JP, Vale JA, Thanacoody HK, Hill SL, Thomas SH. Increasing frequency of severe clinical toxicity after use of 2,4-dinitrophenol in the UK: a report from the National Poisons Information Service. Emergency Medicine Journal 2015, 32, 383-386.
  • Guilding C, Ball SG, Kennedy DJ, Thanacoody R. Development and Implementation of a Clinical Pharmacology, Therapeutics and Prescribing Strand for Newcastle University’s MBBS Degree Programme Using the British Pharmacological Society’s Core Curriculum for Medical Students. pA2 Online: E Journal of the British Pharmacological Society 2015, 13(3).
  • Bateman DN, Dear JW, Thanacoody HKR, Thomas SHL, Eddleston M, Sandilands EA, Coyle J, Cooper JG, Rodriguez A, Butcher I, Lewis SC, Vliegenthart ADB, Veiraiah A, Webb DJ, Gray A. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. The Lancet 2014, 383(9918), 697-704.
  • Kamour A, James D, Lupton DJ, Cooper G, Eddleston M, Vale A, Thompson JP, Thanacoody R, Hill SL, Thomas SHL. Patterns of presentation and clinical features of toxicity after reported use of ([2-aminopropyl]-2,3-dihydrobenzofurans), the 'benzofuran' compounds. A report from the United Kingdom National Poisons Information Service. Clinical Toxicology 2014, 52(10), 1025-1031.
  • Thanacoody HKR, Gray A, Dear JW, Coyle J, Sandilands EA, Webb DJ, Lewis S, Eddleston M, Thomas SHL, Bateman DN. Scottish and Newcastle Antiemetic Pre-treatment for paracetamol poisoning study (SNAP). BMC Pharmacology and Toxicology 2013, 14(1), 20.
  • Hojer R, Troutman WG, Hoppu K, Erdman A, Benson BE, Megarbane B, Thanacoody R, Bedry R, Caravati EM. Position paper update: ipecac syrup for gastrointestinal decontamination. Clinical Toxicology 2013, 51(3), 134-139.
  • Benson BE, Hoppu K, Troutman WG, Bedry R, Erdman A, Hojer J, Megarbane B, Thanacoody R, Caravati EM. Position paper update: gastric lavage for gastrointestinal decontamination. Clinical Toxicology 2013, 51(3), 140-146.
  • Thanacoody RH, Aldridge G, Laing W, Dargan PI, Nash S, Thompson JP, Vale A, Bateman N, Thomas S. National audit of antidote stocking in acute hospitals in the UK. Emergency Medicine Journal 2013, 30(5), 393-396.
  • Antoine DJ, Dear JW, Lewis PS, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology 2013, 58(2), 777-787.
  • Pettie J, Dow M, Sandilands EA, Thanacoody HKR, Bateman DN. An integrated care pathway improves the management of paracetamol poisoning. Emergency Medicine Journal 2012, 29, 482-486.
  • Thanacoody HKR. Thioridazine: The good and the Bad. Recent Patents in Anti-Infective Drug Discovery 2011, 6(2), 92-98.
  • Thanacoody HKR, Jay J, Sherval J. The association between drug-related deaths and prior contact with hospital-based services. Scottish Medical Journal 2009, 54(1), 7-10.
  • Thanacoody R. Extracorporeal elimination in acute valproic acid poisoning. Clinical Toxicology 2009, 47(7), 609-616.
  • Thanacoody HKR. Chronic valproic acid intoxication: reversal by naloxone. BMJ Case Reports 2009, (9), bcr06.2009.1924.
  • Thanacoody HKR, Waring WS. Toxins affecting the cardiovascular system. Clinical Medicine 2008, 8(1), 92-95.
  • Thanacoody HKR, Good AM, Waring WS, Bateman DN. Survey of cases of paracetamol overdose in the UK referred to National Poisons Information Service (NPIS) consultants. Emergency Medicine Journal 2008, 25(3), 140-143.
  • Thanacoody HKR. Thioridazine: resurrection as an antimicrobial agent?. British Journal of Clinical Pharmacology 2007, 64(5), 566-574.
  • Thanacoody HKR. Serotonin syndrome. Medicine 2007, 35(10), 556-557.
  • Thanacoody HKR. Serotonin syndrome. Adverse Drug Reaction Bulletin 2007, (243), 931-934.
  • Thanacoody HKR. Gamma-hydroxybutyric acid. Medicine 2007, 35(11), 619-619.
  • Thanacoody RHK, Daly AK, Reilly JG, Ferrier IN, Thomas SHL. Factors affecting drug concentrations and QT interval during thioridazine therapy. Clinical Pharmacology and Therapeutics 2007, 82(5), 555-565.
  • Salih ISM, Thanacoody RHK, McKay GA, Thomas SHL. Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses. Clinical Pharmacology and Therapeutics 2007, 82(5), 548-554.
  • Thanacoody HKR. Chronic valproic acid intoxication: reversal by naloxone. Emergency Medicine Journal 2007, 24(9), 677-678.

• Book Chapters

  • Thanacoody HKR. Caffeine: massive accidental caffeine overdose treated with continuous veno-venous hemodiafiltration. In: Hema Ketha and Uttam Garg, ed. Toxicology Cases for the Clinical and Forensic Laboratory. London: Academic Press, 2020, pp.239-242.
  • Thanacoody HKR. Drug Interactions. In: Whittlesea C; Hodson K, ed. Clinical Pharmacy and Therapeutics. Amsterdam: Elsevier Health Sciences, 2018, pp.53-65.
  • Thanacoody HKR. Vitamins. In: Bateman DN, Jefferson RD, Thomas SHL, Thompson JP, Vale JA, ed. Oxford Desk Reference Toxicology. Oxford University Press, 2014, pp.176-177.
  • Thanacoody HKR. Serotonin syndrome. In: Bateman DN, Jefferson RD, Thomas SHL, Thompson JP, Vale JA, ed. Oxford Desk Reference Toxicology. Oxford University Press, 2014, pp.79-80.
  • Thanacoody HKR. Pharmacovigilance. In: Bateman DN, Jefferson RD, Thomas SHL, Thompson JP, Vale JA, ed. Oxford Desk Reference Toxicology. Oxford University Press, 2014, pp.14-15.
  • Thanacoody HKR. Methotrexate and other chemotherapeutic agents. In: Bateman DN, Jefferson RD, Thomas SHL, Thompson JP, Vale JA, ed. Oxford Desk Reference Toxicology. Oxford University Press, 2014, pp.168-171.
  • Thanacoody HKR. Malignant hyperpyrexia. In: Bateman DN, Jefferson RD, Thomas SHL, Thompson JP, Vale JA, ed. Oxford Desk Reference Toxicology. Oxford University Press, 2014, pp.81-82.
  • Thanacoody HKR. Drug and alcohol withdrawal. In: Bateman DN, Jefferson RD, Thomas SHL, Thompson JP, Vale JA, ed. Oxford Desk Reference Toxicology. Oxford University Press, 2014, pp.46-47.
  • Thanacoody HKR. Cyanide. In: Bateman DN, Jefferson RD, Thomas SHL, Thompson JP, Vale JA, ed. Oxford Desk Reference Toxicology. Oxford University Press, 2014, pp.229-230.
  • Thanacoody HKR. Drug interactions. In: Walker, R.S., Whittlesea, C, ed. Clinical Pharmacy & Therapeutics. Edinburgh, UK: Churchill Livingstone, 2012, pp.50-61.

• Conference Proceedings (inc. Abstracts)

  • Gilfillan CM, Bradley S, Gray LA, Bradberry SM, Veiraiah A, Thanacoody RHK. Use of antidotes held in supra-regional holding centres in the UK: a retrospective audit of clinical enquiries reported to the UK National Poisons Information Service (NPIS). In: 45th Congress of European Association of Poison Centres and Clinical Toxicologists. 2025, Glasgow: Taylor & Francis Inc.
  • Donohoe E, Lee R, Gray LA, Veiraiah A, Thanacoody RHK. The changing profile of button battery ingestion: a review of cases reported to the UK National Poisons Information Service. In: 45th Congress of European Association of Poison Centres and Clinical Toxicologists. 2025, Glasgow: Taylor & Francis Inc.
  • Moonira TN, Bradberry SM, Gray LA, Veiraiah A, Thanacoody RHK. Telephone enquiries to UK NPIS about dinitrophenol pre- and post-reclassification under the Poisons Act. In: 45th Congress of European Association of Poison Centres and Clinical Toxicologists. 2025, Glasgow: Taylor & Francis Inc.
  • Tierney DJ, Kisimbo K, Pitt E, Thanacoody RHK. Severe ethylene glycol poisoning via central line injection. In: 45th Congress of European Association of Poison Centres and Clinical Toxicologists. 2025, Glasgow: Taylor & Francis Inc.
  • Gziut T, Thanacoody RHK, Hill SL, Wiltshire S, Logan I, Boxshall L. Acute kidney injury (AKI) following recreational vaping of the synthetic cannabinoids: MDMB-4-en-PINACA and 4F-MDMB-BUTINACA. In: 45th Congress of European Association of Poison Centres and Clinical Toxicologists. 2025, Glasgow: Taylor & Francis Inc.
  • Moyns E, Jagpal PS, Pucci M, Jutley G, Sandilands EA, Gray LA, Thanacoody RHK, Bradberry SM. Use of cyproheptadine for the treatment of serotonin toxicity: a 10-year review of enquiries to the National Poisons Information Service (NPIS). In: 44th Congress of European Association of Poison Centres and Clinical Toxicologists. 2024, Munich, Germany: Taylor & Francis Inc.
  • Eagling VA, Thanacoody RHK, Gray LA, Bradberry SM, Sandilands EA. The use of fomepizole in the management of toxic alcohol ingestions reported to the UK National Poisons Information Service: a 3-year study. In: 44th Congress of European Association of Poison Centres and Clinical Toxicologists. 2024, Munich, Germany: Taylor & Francis Inc.
  • Thomas E, Bradberry SM, Sandilands EA, Thanacoody RH, Gray LA, Coulson JM. A ten-year review of intentional paracetamol ingestions in children and adolescents - is there a distinct age separating intentional and unintentional overdoses in these populations?. In: 44th International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT). 2024, Munich: Taylor & Francis Inc.
  • McKinty A, Bradberry SM, Sandilands EA, Thanacoody RHK, Gray L, Coulson JM. Retrospective study of serotonin syndrome enquiries to UK National Poisons Information Service in 2021. In: 43rd Congress of European Association of Poison Centres and Clinical Toxicologists. 2023, Palma, Mallorca: Taylor & Francis Inc.
  • Eagling VA, Thanacoody RHK, Gray LA, Bradberry SM, Sandilands EA. Poisoning with cardiac glycoside containing plants reported to the UK NPIS: a 7 year study. In: 43rd Congress of European Association of Poison Centres and Clinical Toxicologists. 2023, Palma: Clinical Toxicology.
  • Eagling VA, Jackson G, Thanacoody RHK, Gray LA, Bradberry SM, Sandilands EA. The use of antidotes in the management of methotrexate poisoning: UK Experience. In: 42nd Congress of European Association of Poison Centres and Clinical Toxicologists. 2022, Tallinn: Clinical Toxicology.
  • Jackson G, Eagling V, Thanacoody R, Gray L, Bradberry S, Sandilands E. The use of antidote in the management of digoxin poisoning. 2022, Toxicological Sciences.
  • Pucci M, Moyns E, Jutley G, Crisp R, Sandilands E, Gray L, Thanacoody R, Bradberry S. Recreational nitrous oxide abuse: Trends in enquiries to the UK National Poisons Information Service, 2011-2020. In: British Journal of Clinical Pharmacology. 2022, Wiley.
  • Eagling VA, Jackson G, Thanacoody RHK, Gray LA, Bradberry SM, Sandilands EA. Oral methotrexate poisoning reported to the UK National Poisons Information Service (NPIS). In: 42nd Congress of European Association of Poison Centres and Clinical Toxicologists. 2022, Tallinn.
  • Williams H, Jagpal P, Bradberry S, Sandilands EA, Gray LA, Thanacoody RHK. Fatal propranolol overdoses reported to the UK National Poisons Information (NPIS) over 5 years, 2017-2021. In: 42nd Congress of European Association of Poison Centres and Clinical Toxicologists. 2022, Tallinn: Clinical Toxicology.
  • Alrossies AS, Motohashi K, Wiltshire S, Hill SL, Thomas SHL, Thanacoody RHK. Efficacy of a 12h intravenous acetylcysteine (SNAP) regimen following large single acute paracetamol overdose. In: 42nd Congress of European Association of Poison Centres and Clinical Toxicologists. 2022, Tallinn: Clinical Toxicology.
  • Eagling V, Jackson G, Klatka M, Thanacoody R, Gray L, Bradberry S, Sandilands E. Digoxin poisoning reported to the UK National Poisons Information Service (NPIS). 2022, Toxicological Sciences.
  • Alrossies AS, Ross J, Harnett J, Wood DM, Dargan PI, Thanacoody HKR. Efficacy of a 12h intravenous acetylcysteine (SNAP) regimen following single acute paracetamol overdose. 2020, Clinical Toxicology.
  • Alrossies AS, Thanacoody RHK, Harnett J. Derivation of a clinical decision rule allowing earlier discharge of patients with paracetamol poisoning after a shorter 12-hour acetylcysteine (SNAP) protocol. 2019, Clinical Toxicology.
  • Thanacoody HKR, Nijhout HF, Reed MC, Thomas SHL. Mathematical modelling of the effect of late administration of a novel acetylcysteine regimen based on the SNAP trial on hepatic glutathione regeneration and hepatocyte death following simulated acetaminophen overdose. In: North American Congress of Clinical Toxicology. 2017, Vancouver: Taylor & Francis.
  • Thanacoody HKR, Nijhout HF, Reed MC, Thomas SHL. Mathematical modelling of the effect different acetylcysteine regimens on hepatic glutathione regeneration and hepatocyte death following simulated acetaminophen overdose. In: North American Congress of Clinical Toxicology. 2017, Vancouver: Taylor & Francis.
  • Thanacoody HKR, Thomas SHL. Pharmacokinetic modelling of a high dose acetylcysteine regimen based on the SNAP trial. In: 36th International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT). 2016, Madrid Spain: Taylor and Francis.
  • Thanacoody HKR, Thomas SHL. Pharmacokinetic modelling of a high dose acetylcysteine regimen based on the SNAP trial. In: 36th Congress of the European Association of Poisons Centres and Clinical Toxicologists. 2016, Madrid, Spain.
  • Thanacoody HKR, Nijhout FH, Reed MC, Thomas SHL. Mathematical modelling of the effect of a high dose acetylcysteine regimen based on the SNAP trial on hepatic glutathione regeneration and hepatocyte death. In: 36th International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT). 2016, Madrid, Spain: Taylor & Francis.
  • Kamour A, James D, Lupton DJ, Cooper G, Eddleston M, Vale JA, Thompson JP, Thanacoody RHK, Hill SL, Thomas SHL. Toxicity after reported use of "benzofury" compounds ([2-aminopropyl]-2,3-dihydrobenzofurans) compared with mephedrone: A report from the UK National Poisons Information Service. In: XXXIV International Congress of EAPCCT. 2014, Brussels, Belgium: Informa Healthcare.
  • Kamour A, Gwynnette D, George N, Cooper G, Lupton DJ, Eddleston M, Thompson JP, Vale JA, Thanacoody RHK, Hill S, Thomas SHL. Severe toxicity after use of 2,4-dinitrophenol reported to the UK National Poisons Information Service. In: XXXIV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT). 2014, Brussels, Belgium: Informa Healthcare.
  • Kamour A, James D, Spears R, Cooper G, Lupton DJ, Eddleston M, Thompson JP, Vale JA, Thanacoody RHK, Hill S, Thomas SHL. Patterns of presentation and clinical toxicity after reported use of alpha methyltryptamine in the United Kingdom: A report from the UK National Poisons Information Service. In: XXXIV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT). 2014, Brussels, Belgium: Informa Healthcare.
  • Elamin M, Thanacoody R. Paracetamol-induced hepatotoxicity despite paracetamol concentrations below treatment threshold. In: International Congress of EAPCCT. 2013, Copenhagen, Denmark: Informa Healthcare.
  • Brown J, Thanacoody R. Paracetamol-induced hepatotoxicity at therapeutic doses. In: XXXIII International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT). 2013, Copenhagen, Denmark: Informa Healthcare.
  • Dear JW, Antoine DJ, Starkey-Lewis P, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK. Mechanistic biomarkers provide early and sensitive detection of paracetamol-induced acute liver injury at first presentation to hospital. In: XXXIII International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT). 2013, Copenhagen, Denmark: EAPCCT.
  • Thanacoody HKR. Clinical Toxicology of Ayurvedic Medicines. In: International Congress of EAPCCT. 2013, Copenhagen, Denmark: Informa Healthcare.
  • Thanacoody HKR, Weatherall I, Davies J, Thomas SHL. Treatment of severe toxic alcohol and glycol poisoning in the UK. In: International Congress of EAPCCT. 2012, London.
  • Thanacoody HKR, Weatherall I, Davies J, Thomas SHL. Toxic Alcohol and glycol poisoning in the UK- a 12 month prospective follow-up study. In: International Congress of EAPCCT. 2012, London.
  • Thanacoody HKR, Aldridge G, Laing W, Nash S, Dargan PI, Vale JA, Bateman DN, Thompson JP, Thomas SHL. Antidote Stocking in Acute Hospitals in the United Kingdom. In: International Congress of the European Association of Poisons Centres and Clinical Toxicologists. 2012, London: Informa Healthcare.
  • Thanacoody HKR, Nash S, Vale JA, Bateman DN, Thompson JP, Dargan PI, Thomas SHL. Antidote Stocking in Acute Hospitals in the United Kingdom. In: International Congress of the European Association of the Poisons Centres and Clinical Toxicologists. 2012, London, UK: Informa Healthcare.
  • Amaral L, Abbate E, Boeree M, Gillespie S, Thanacoody R, Udwadia Z, vanIngen J, vanSoolingen D, Viveiros M. In vitro, ex vivo and in vivo studies indicate that neuroleptic thioridazine cures multi-drug resistant tuberculosis. In: 21st European Congress of Clinical Microbiology and Infectious Diseases and the 27th International Congress of Chemotherapy. 2011, Milan, Italy.
  • Weatherall I, Thanacoody HKR, Davies J, Cooper G, Thomas SHL. Characteristics of Toxic Alcohol and Glycol Poisoning in the UK. In: International Congress of the European Association of Poisons Centres and Clinical Toxicologists. 2011, Dubrovnik, Croatia: Informa Healthcare.
  • Pettie JM, Dow MA, Thanacoody HKR, Sandilands EA, Bateman DN. Integrated care pathway for the management of the paracetamol poisoned patient. In: XXX International Congress of EAPCCT. 2010, Bordeaux.
  • Thanacoody HKR. Clinical Toxicology of Ayurvedic Medicines. In: EAPCCT XXVIII International Congress. 2008, Seville, Spain: Informa Healthcare.
  • Thanacoody HKR, Daly AK, Reilly JG, Ferrier IN, Thomas SHL. Genetic factors influencing steady-state plasma concentrations of thioridazine and its metabolites. In: British Journal of Clinical Pharmacology: Meeting of the British Pharmacological Society Clinical Pharmacology Section. 2006, London, UK: Wiley-Blackwell Publishing Ltd.
  • Thanacoody HKR, Daly AK, Reilly JG, Ferrier IN, Thomas SHL. Effects of CYP2D6 genotype on QTc interval in recipients of thioridazine. In: British Journal of Clinical Pharmacology: Meeting of the British Pharmacological Society Clinical Pharmacology Section. 2006, London, UK: Wiley-Blackwell Publishing Ltd.
  • Salih I, Thanacoody HKR, McKay G, Thomas SHL. Effect of single-dose thioridazine and mesoridazine on the QTc interval in healthy adults. In: British Journal of Clinical Pharmacology: Meeting of the British Pharmacological Society Clinical Pharmacology Section. 2006, London, UK: Wiley-Blackwell Publishing Ltd.
  • Salih I, Thanacoody HKR, McKay G, Thomas SHL. Effect of single-dose chlorpromazine on the QTc interval in healthy adult volunteers. In: British Journal of Clinical Pharmacology: Meeting of the British Pharmacological Society Clinical Pharmacology Section. 2006, London, UK: Wiley-Blackwell Publishing Ltd.

• Editorials

  • Wood DM, Dear JW, Thanacoody R, Juurlink DN, Chiew AL, Dargan PI. Antidotes in the management of poisoned patients: What have we gained over the last decade?. British Journal of Clinical Pharmacology 2025, 91(3), 593-594.
  • Dear JW, Dargan PI, Juurlink DN, Thanacoody RHK, Wood DM. Introduction to a series of Pro/Con papers in Clinical Toxicology. British Journal of Clinical Pharmacology 2022, 88(1), 56-57.

• Letters

  • Bateman DN, Dear JW, Thanacoody HKR, Thomas SHL, Eddleston M. Treatment of paracetamol overdose - Authors' reply. The Lancet 2014, 383(9926), 1383-1383.
  • Bateman DN, Thanacoody HK, Waring WS. Digitalis intoxication induced by paroxetine co-administration. The Lancet 2006, 368(9551), 1962-1963.

• Note

  • Dear JW, Dargan PI, Eddleston M, Thanacoody RH, Thomas SHL. Response to the letter from Wong et al. EClinicalMedicine 2019, 14, 13-13.

• Online Publication

  • Thanacoody R. Opioid overdose. BMJ Publishing Group, 2025. Available at: https://bestpractice.bmj.com/topics/en-gb/339.

• Reviews

  • King A, Thanacoody RHK. Opioid overdose: evidence-based management guidelines and new antidote development. Medical Research Archives 2025, 13(10).
  • Gziut T, Thanacoody R. L-carnitine for valproic acid-induced toxicity. British Journal of Clinical Pharmacology 2025, 91(3), 636-657.
  • Andrews P, Anseeuw K, Kotecha D, Lapostolle F, Thanacoody R. Diagnosis and practical management of digoxin toxicity: a narrative review and consensus. European Journal of Emergency Medicine 2023, 30(6), 395-401.
  • Motohashi K, Thanacoody RH. Toxicology in the emergency department: what's new?. British Journal of Hospital Medicine 2022, 83(9), 1-16.
  • Thompson JP, Watson ID, Thanacoody HKR, Morley S, Thomas SHL, Eddleston M, Vale JA, Bateman DN, Krishna CV. Guidelines for laboratory analyses for poisoned patients in the United Kingdom. Annals of Clinical Biochemistry 2014, 51(3), 312-325.
  • Thanacoody HKR, Thomas SHL. Tricyclic antidepressant poisoning: Cardiovascular toxicity. Toxicological Reviews 2005, 24(3), 205-214.
  • Bradberry SM, Thanacoody HKR, Watt BE, Thomas SHL, Vale JA. Management of the cardiovascular complications of tricyclic antidepressant poisoning: role of sodium bicarbonate. Toxicological Reviews 2005, 24(3), 195-204.
  • Thanacoody HKR, Thomas SHL. Antidepressant poisoning. Clinical Medicine 2003, 3(2), 114-118.