Staff Profile

Introduction

I am a Consultant Paediatrician in Allergy and Immunology at The Great North Children's Hospital (GNCH), Newcastle upon Tyne Hospitals NHS Foundation Trust.

Clinical - I specialise in complex severe multisystem allergic disease with our current programmes focusing on Food and Asthma Allergy prevention focusing on treatment at home, in a digital manner to prevent, whilst trying to cure, disease.

Research - I am also a Senior Lecturer within the Faculty of Medicine where I am a Chief and Principle Investigator within the themes of Reproduction, Development and Child Health Research (PHSI) and Immunity and Inflammation (TCRI and BI).

I read for my PhD under the tutelage of Professors Graham Roberts, John Holloway, Tony Williams, Hasan Arshad (Southampton University) and Catherine Thornton (Swansea University) (2018) on 'Immune tolerance in early childhood'. I continue to develop an understanding of childhood allergic diseases with an interest in immune tolerance, dysbiosis and Th2 related allergic inflammatory disorders.

We develop and deliver phase I/II/III portfolio Clinical Trials within the ORECHESTRA Programme of the Great North Children's Hospital Research Community (GNCH-RC), translating the development of new diagnostic immune mechanisms, immunotherapy and novel targeted therapies into clinical practice.

Education - Together within the 'Model of Seamless Allergy Care', we improve clinical care and delivery to our patients within the Research and Education of Allergic Disease in Children (REACH) programmes.

Qualifications

BSc(Hons) St Andrews University UK

MBChB Edinburgh University UK

MRCPCH London UK

MSc Child Health University College London UK

FRCPCH London UK

PhD Southampton University UK

Roles and responsibilities

• Vice President for Services - British Society Allergy Clinical Immunology, 2022 -
• Secretary - British Society of Allergy Clinical Immunology Registry for Immunotherapies (BRIT), 2020 -
• Fellow - Royal College of Paediatrics and Child Health, London
• Member - European Academy of Allergy and Clinical Immunology, Taskforce for Anaphylaxis, 2019 - 2023
• Member - Royal College of Paediatrics and Child Health, SPIN Curriculum, 2019 - 2021
• Paediatric stage 4 lead - undergraduate immunology allergy curriculum, 2020 - 2023
• Faculty - Allergy eModule, Newcastle University (Lead Immunology/ skin), 2014 -2022
• Faculty - MSc Allergy, Southampton University, 2008 -2025
• Member - British Society Allergy Clinical Immunology, Allergy Education Network (BAEN) Committee, 2019 - 2022
• Member Northern Paediatric Allergy Network, Chair, 2013 - 2018

Areas of expertise

• Th2 allergic inflammation
• Oral immunotherapy
• Targeted therapies
• Anaphylaxis
• Drug allergy and desensitisation
• Transplant associated allergies
• Models and services of care

Awards

• Barry Kay Award, Primary Care, British Society of Allergy and Clinical Immunology, 2025
• Barry Kay Award, Clinical Paediatrics, British Society of Allergy and Clinical Immunology, 2020
• Finalist, Research Supervisor of the Year, Newcastle University, 2020
• Education Category Award, RCPCH Drugs and Bugs sepsis podcast, Bright Ideas in Health Awards, 2019
• Service Improvement Category Award, Honeycomb Model of Seamless Allergy Care, Bright Ideas in Health Awards, 2017
• NIHR NENC Commercial Study Team of the Year, 2017
• NIHR Leading Principle Investigator Award, 2016

Links

Contact us | Research and Education in Allergic Disease of Children (REACH)

Staff Profile | Faculty of Medical Sciences | Newcastle University

Dr Louise Michaelis - Newcastle Hospitals NHS Foundation Trust

Websites:

ORCiD ID: 0000 0001 8229 154X

Google Scholar: https://scholar.google.co.uk/citations?user=tyazG1IAAAAJ&hl=enLinkedIn: https://uk.linkedin.com/in/louise-jane-michaelis-86794a90

Research Gate: https://www.researchgate.net/profile/Louise-Michaelis

Outline



The Research and Education of Allergic Disease of Children Programme (REACH) focuses on increasing the understanding of childhood allergic disease and translating cutting edge clinical discoveries to support the development of new diagnostic immune mechanistic platforms and targeted therapies.

Within the three Institutes of the Faculty of Medicine Sciences, our teams work together to improve the health, care and well-being of children with allergic disease. In collaboration with the Clinical Research Facility (CRF) of the Great North Children's Hospital Research Community (GNCH-RC) we bring our research to the clinical interface.

Our 'Origins of CHildhood Eosinophilic and Systemic Related Allergic Disease' Programme (ORCHESTRA) moves into the second decade with the following Work Packages namely:

Current ORCHESTRA projects

• ADAGIO - Atopic Disease with Allergic Gastrointestinal Inflammatory Origins
• ALLEGRO - Allergic Eosinophilic Disease with Gene Related Origins
• SYMPHONY - Symbiotic and Microbiome origins of Nutrition in the Young
• MEDICI - Mechanisms of Eosinophilic Th2 Disease In Children from Infancy
• PIANO - Psychological Impact of Allergic Disease and Nutritional Obstacles
• SCALE - Symptoms and Clinical manifestations of Allergy

The Clinical and Translational Research team

Within the Theme of Immunity and Inflammation, scientists, academics and clinical researchers collaborate with a goal to increase awareness and understanding of allergic inflammatory diseases. Alongside the Flow Cytometry Core Facility, and collaborations with the Universities of Liverpool, Kings College London, Southampton, Imperial College and Manchester University, we aim to translate laboratory findings into new diagnostic platforms. Current MRES Newcastle University projects are diverse with our basic science team collaborating with the GNCH- Research Community and GNCH Clinical Research Facility to develop and support epidemiological, observational and interventional studies. Our programme for 2026 evolves around allergy prevention, in the community, on a digital platform.

Phase I, II, III Clinical Trials - In set up:

1. HYST Study - Drug Hypersensitivity Mechanistic Study

Phase I, II, III Clinical Trials - ongoing:

1. Parent and Baby Project PBP) - Food Allergy Prevention
2. Paediatric Prevention of Asthma Study - (PAPA) - Asthma Prevention
3. Basophil Activate Tests - (BAT) Study
4. Oral Immunotherapy to real foods (NATASHA)

Clinical trials - completed:

1. BREAD - Biomarkers of Eosinophilic Allergic Disease
2. PRESTO - Synbiotics for IgE mediated cow's milk protein allergy
3. TEMPO - Feeding patterns in infancy and associated reported allergy symptoms
4. ASSIGN - Microbiome and Non IgE mediated cow's milk allergy
5. DREAM - Desensitisation in infants with IgE mediated cow's milk protein allergy
6. SNIFFLE I,II,III,IV - Infuenz nasal vaccine in children with IgE mediated egg allergy, and asthma

Contact us | Research and Education in Allergic Disease of Children (REACH)

We believe teaching and networking are vital to bring the very best clinical practice and research to our region and beyond.

We support the Medical School, Newcastle University undergraduate stage 4, Student Selected Component (SSC) and Masters of Research (MRes) Programmes.

Regionally and locally, the Newcastle Allergy team continue to actively support the Northern Paediatric Allergy Group (NPAG) uniting research and education to the 8 District Hospitals of the North East.

The 'Research and Education of Allergic Disease of Children Programme' (REACH) focuses on three strategies:

1. REACH-OUT - 'Model of Seamless Allergy Care' to outreach to the primary and secondary care to promote the education and training of allergic disease.
2. REACH-FAR - Faculty of Allergy Research for all who wish to be involved from school students, to local or international research students to PhD level of tutelage to have digital educational access.
3. REACH-IN - GNCH Fund raising platform for Department of Paediatric Allergy as part of GNCH Foundation Charity.

Since 2013, I remain involved in academia and research as a full time clinical paediatrician. As previous Chair of NPAG and current Vice President for Services of the British Society of Allergy and Clinical Immunology, I remain committed to develop and enhance the REACH Programme, to champion the current 'Fit for Future' campaign of NHS England i) from hospital to community, ii) from analogue to digital and iii) from sickness to prevention.

Digital Platforms:

1. https://www.beatanaphylaxis.co.uk/
2. https://www.beatasthma.co.uk/
3. Contact us | Research and Education in Allergic Disease of Children (REACH)
4. Paediatric allergy service - Newcastle Hospitals NHS Foundation Trust
5. What happens in clinic - Newcastle Hospitals NHS Foundation Trust
6. https://www.newcastle-hospitals.nhs.uk/wp-content/uploads/2025/12/GNCH-reach-in-flyer.pdf

• Articles

  • Hendrickx DM, Long M, Wopereis H, van der Molen RG, Belzer C, Chatchatee P, Nowak-Wegrzyn A, Lange L, Benjaponpitak S, Chong KW, Sangsupawanich P, van Ampting MTJ, Oude Nijhuis MM, Harthoorn LF, Langford JE, Knol J, Knipping K, Garssen J, Trendelenburg V, Pesek R, Davis CM, Muraro A, Erlewyn-Lajeunesse M, Fox AT, Michaelis LJ, Beyer K, Noimark L, Stiefel G, Schauer U, Hamelmann E, Peroni D, Boner A. Identification of potential inflammation markers for outgrowth of cow’s milk allergy. PLoS ONE 2025, 20(9), e0331462.
  • Chatchatee P, Breedveld AC, Eussen SRBM, Nowak-Wegrzyn A, Lange L, Benjaponpitak S, Chong KW, Sangsupawanich P, Wopereis H, Oude Nijhuis MM, Langford JE, Kostadinova AI, Trendelenburg V, Pesek R, Davis CM, Muraro A, Erlewyn-Lajeunesse M, Fox AT, Michaelis LJ, Beyer K. Effects of a specific synbiotic blend on fecal short-chain fatty acids and gut inflammation in cow's milk-allergic children receiving amino acid–based formula during early life: results of a randomized controlled trial (PRESTO study). Frontiers in Allergy 2025, 6, 1667162.
  • Turner PJ, Bright A, Michaelis LJ, Quint JK. Economic modelling of providing ‘spare’ adrenaline autoinjectors to all schools to improve the management of anaphylaxis. Archives of Disease in Childhood 2025, epub ahead of print.
  • Michaelis LJ, Owen T, Bright AD, Sherwin-Robson L. Adrenaline Auto-Injector Prescribing in Primary Care in England: An Analysis of Non-Standard Dosing. Clinical and Experimental Allergy 2026, 56(1), 30-40.
  • Hendrickx DM, Savova MV, Zhu P, An R, Boeren S, Klomp K, Mutte SK, Wopereis H, van der Molen RG, Harms AC, Belzer C, Chatchatee P, Nowak-Wegrzyn A, Lange L, Benjaponpitak S, Chong KW, Sangsupawanich P, van Ampting MTJ, Nijhuis MMO, Harthoorn LF, Langford JE, Knol J, Knipping K, Garssen J, Trendelenburg V, Pesek R, Davis CM, Muraro A, Erlewyn-Lajeunesse M, Fox AT, Michaelis LJ, Beyer K, Noimark L, Stiefel G, Schauer U, Hamelmann E, Peroni D, Boner A. A multi-omics machine learning classifier for outgrowth of cow's milk allergy in children. Molecular Omics 2025, 21(4), 343-352.
  • Chatchatee P, Nowak-Wegrzyn A, Lange L, Benjaponpitak S, Chong KW, Sangsupawanich P, Eussen SRBM, van Ampting MTJ, Oude Nijhuis MM, Langford JE, Trendelenburg V, Pesek R, Davis CM, Muraro A, Erlewyn-Lajeunesse M, Fox AT, Michaelis LJ, Beyer K. Tolerance development in cow's milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study). Journal of Pediatric Gastroenterology and Nutrition 2024, 78(3), 699-703.
  • Marrs T, Patel N, Burrell S, Rampersad A, Minshall E, Leech S, Chandratilleke D, Dempsey J, Ludman S, Roberts G, Michaelis LJ, Brough HA, Karanam S, Batt R, Moulsdale P, Steifel G, Tiwana K, Smith H, Knight K, Vazquez-Ortiz M, Vyas D, Turner PJ, Makwana N. BSACI guidance for the implementation of Palforzia® peanut oral immunotherapy in the United Kingdom: A Delphi consensus study. Clinical and Experimental Allergy 2024, 54(7), 459-469.
  • McPherson T, Cork MJ, Goodhead C, Michaelis LJ, Flohr C, Petrovic M, Hennessy L, Rajkovic I, Hudson R. A real-world retrospective observational study exploring NHS resource use in England for the management of moderate-to-severe atopic dermatitis in secondary care for children and adolescents. Pediatric Dermatology 2023, 40(1), 50-63.
  • Faulkner AL, Grayling M, Shillitoe B, Brodlie M, Michaelis LJ. Characterising the allergic profile of children with cystic fibrosis. Immunity, Inflammation and Disease 2022, 10(1), 60-69.
  • de Silva D, Singh C, Muraro A, Worm M, Alviani C, Cardona V, DunnGlvin A, Garvey LH, Riggioni C, Angier E, Arasi S, Bellou A, Beyer K, Bijlhout D, Bilo MB, Brockow K, Fernandez-Rivas M, Halken S, Jensen B, Khaleva E, Michaelis LJ, Oude Elberink H, Regent L, Sanchez A, Vlieg-Boerstra B, Roberts G. Diagnosing, managing and preventing anaphylaxis: Systematic review. Allergy 2021, 76(5), 1493-1506.
  • Shillitoe B, Lee JC, Hussien M, Beintaris I, Stothard M, Johnston M, Dallal HJ, Michaelis LJ, Attwood S, Dhar A. Clinical spectrum of paediatric and adult eosinophilic oesophagitis in the North East of England from 2016 to 2019. Frontline Gastroenterology 2021, 13(3), 231-236.
  • Lippeveld M, Knill C, Ladlow E, Fuller A, Michaelis LJ, Saeys Y, Filby A, Peralta D. Classification of Human White Blood Cells Using Machine Learning for Stain-Free Imaging Flow Cytometry. Cytometry Part A 2019, 97(3), 308-319.
  • Wopereis H, Van Ampting MTJ, Cetinyurek-Yavuz A, Slump R, Candy DCA, Butt AM, Peroni DG, Vandenplas Y, Fox AT, Shah N, Roeselers G, Harthoorn LF, Michaelis LJ, Knol J, West CE. A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow's milk allergic infants: A randomized controlled trial. Clinical and Translational Allergy 2019, 9(1), 27.
  • Turner PJ, Southern J, Andrews NJ, Miller E, Erlewyn-Lajeunesse M. Safety of live attenuated influenza vaccine in young people with egg allergy:multicentre prospective cohort study. British Medical Journal 2015, 351, h6291.
  • Zolkipli Z, Roberts G, Cornelius V, Clayton B, Pearson S, Michaelis L, Djukanovic R, Kurukulaaratchy R, Arshad H. Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood. Journal of Allergy and Clinical Immunology 2015, 136(6), 1541-1547.
  • Cheetham T, Plumb E, Callaghan J, Jackson M, Michaelis L. Dietary restriction causing iodine-deficient goitre. Archives of Disease in Childhood 2015, 100(8), 784-786.
  • Khatami A, Snape MD, Ohene-Kena B, Young K, Oeser C, Michaelis LJ, Macleod E, Smee H, VanDerMeeren O, Leyssen M, Caubet M, Yu LM, Heath PT, Faust SN, Finn A, Pollard AJ. Phase II study of a three-dose primary vaccination course of DTPa-IPV/Hib-MenC-TT followed by a 12 month Hib-MenC-TT booster in healthy infants. Pediatr Infect Dis J 2013, 32(6), 675-81.
  • Meyer R, Fleming C, Ortega-Dominguez G, Lindley K, Michaelis L, Thapar N, Elawad M, Chakravarti V, Fox AT, Shah N. Manifestations of food protein induced gastrointestinal allergies presenting to a single tertiary paediatric gastrointestinal unit. World Allergy Organ Journal 2013, 6(1), 13.
  • Walker WT, deWhalley P, Andrews N, Oeser C, Casey M, Michaelis L, Hoschler K, Harrill C, Moulsdale P, Thompson B, Jones C, Chalk J, Kerridge S, John TM, Okike I, Ladhani S, Tomlinson R, Heath PT, Miller E, Faust SN, Snape MD, Finn A, Pollard AJ. H1N1 antibody persistence 1 year after immunisation with an adjuvanted or whole virion pandemic vaccine and immunogenicity and reactogenecity of subsequent seasonal influenza vaccine: a multi-center follow-on study. Clin Infect Dis 2012, 54(5), 661-9.
  • Andrews NJ, Walker WT, Finn A, Heath PT, Collinson AC, Pollard AJ, Snape MD, Faust SN, Waight PA, Hoschler K, Sheasby L, Waddington C, Kerridge S, Chalk J, Reiner A, John T, Fletcher M, Allen R, Fineman N, Wilkins S, Casey M, Michaelis L, Oeser C, Okike I, Ladhani S, Miller E. Predictors of immune response and reacto-genecity to AS03B-adjuvanted split virion and non-adjuvanted whole virion H1N1 (2009) pandemic influenza vaccines. vaccine 2011, 29(45), 7913-9.
  • Kufeji O, Withana K, Michaelis L. Chronic recurrent multifocal osteomyelitis is a differential of childhood limp. Arch Dis Child 2006, 91(1), 30.
  • McIntosh N, Michaelis L, Barclay C, Muir M, Stephen R, Sedowofia K. Dissociation of osmoregulation from plasma arginine vasopressin levels following thermal injury in childhood. Burns 2000, 26(6), 543-7.

• Book Chapters

  • Noakes PS, Michaelis LJ. Innate and adaptive immunity. In: Diet, Immunity and Inflammation. Cambridge: Woodhead Publishing Limited, 2013, pp.3-33.
  • Calder PC, Yaqoob P. Chapter 1: Innate and Adaptive Immunity. In: Diet, Immunity and Inflammation. 2013.

• Conference Proceedings (inc. Abstracts)

  • Dean HJ, McKean M, Gardner J, Pentland J, Vance G, Gennery A, Michaelis LJ. Respiratory acute life-threatening event (R-ALTE) reviews from Paediatric Intensive Care Unit (PICU) and the association with food allergy (FA) at Great North Children's Hospital (GNCH), Newcastle, UK - part 2. In: European Academy of Allergy and Clinical Immunology Congress. 2016, Vienna, Austria: Wiley-Blackwell Publishing Ltd.
  • Dean HJ, McKean M, Gardner J, Pentland J, Vance G, Gennery A, Michaelis LJ. Respiratory Acute Life-Threatening Event (R-ALTE) admissions to Paediatric Intensive Care Unit (PICU) and the association with Food Allergy (FA) at Great North Children's Hospital (GNCH), Newcastle, UK - Part 1. In: European Academy of Allergy and Clinical Immunology Congress. 2016, Vienna, Austria: Wiley-Blackwell Publishing Ltd.
  • Michaelis LJ, Wopereis H, Van Ampting MT, Nijhuis MMO, Candy DC, Butt AM, Peroni DG, Fox AT, Shah N, Harthoorn LF, Knol J. An amino acid-based formula with synbiotics affects faecal microbiota in Non-IgE mediated cow's milk allergic infants. In: European Academy of Allergy and Clinical Immunology Congress. 2016, Vienna, Austria: Wiley-Blackwell Publishing Ltd.
  • Davidson NA, Vines J, Bartindale T, Comber R, Balaam M, Mcnaney D, Sutton S, Green D, Michaelis L, Salter L, Olivier P, Vance G. Educating adolescents at risk of anaphylaxis (the ERA study). In: European Academy of Allergy and Clinical Immunology Congress. 2015, Barcelona, Spain: Wiley-Blackwell.

• Editorials

  • Khan S, Krishna MT, Michaelis LJ, Dawson TC, Marriage D, Thursby-Pelham A, Pur Ozyigit L, Jones C, Regent L, Erlewyn-Lajeunesse M. BSACI Registry for Immunotherapy (BRIT): Providing safe and effective immunotherapy for allergies and urticaria. Clinical and Experimental Allergy 2021, 51(8), 985-988.
  • Netts P, Michaelis LJ. An interpretation of the new international MAP guideline for the management of Milk Allergy in Primary Care. Clinical and Translational Allergy 2017, 7, 34.

• Letter

  • Smith PK, Soutter V, Michaelis LJ, Strobel S. Chromosome 18q21.2-21.3 deletions associated with anaphylaxis, severe eczema and allergic airways disease. J Allergy Clin Immunology 2013, 6(1), 13.