Staff Profile

I am a paediatric respiratory clinician and academic with an interest in cystic fibrosis. My research involves the development and utilisation of airway epithelial models to investigate abnormal membrane transport in chronic respiratory diseases such as cystic fibrosis. My clinical interests include cystic fibrosis and sleep medicine.

Current role:

• Honorary Consultant in Paediatric Respiratory Medicine, Great North Children's Hospital
• NHIP Senior Clinical Fellow, Newcastle University

Previous positions:

• NIHR Academic Clinical Lecturer in Paediatric Respiratory Medicine Newcastle University 2019 - 2022
• Paediatric Respiratory Subspecialty Trainee, Northern Deanery 2018-2022
• Wellcome Trust Clinical Research Training PhD Fellowship, Newcastle University 2015-2018
• Paediatric Trainee, Northern Deanery 2010-2015

Professional roles and responsibilities:

• UK Cystic Fibrosis Trust Standards of Care Working Group 2023 to present
• Paediatric Trainee Representative, UK Cystic Fibrosis Medical Association Committee 2019-2021
• Newcastle Child Health Academic Steering Group Committee 2019 to present
• Peer reviewer (BMJ, BMJ Paediatrics Open, IJMS, NIHR RDS)
• FMS Ethics Committee 2019 to present

Qualifications:

• PhD, Newcastle University 2019
• MRCPCH, Royal College of Paediatrics and Child Health 2012
• MRes, Newcastle University 2006
• MBBS, Newcastle University 2007

My Wellcome Trust funded PhD research involved the investigation of an alternative chloride channel in the cystic fibrosis airway. During this time I established a programme to develop and establish differentiated in vitro models to investigate the nasal and bronchial epithelium. I utilised these models to investigate dysfunctional ion transport using electrophysiological techniques. I was awarded a Starter Grant from the Academy of Medical Sciences during my NIHR Clinical Lecturership to explore the impact of CFTR modulation in the paediatric CF airway.

My ongoing research within my current role involves the ongoing investigation of the dysfunctional airway epithelial environment in cystic fibrosis and other chronic suppurative diseases such as bronchiectasis.

Biomedical Sciences Undergraduate Programme: Health and disease at mucosal surfaces module

Physiology Undergraduate Programme: Respiratory physiology module

Supervision of undergraduate and postgraduate students

ALSG Newborn Life Support Certified Instructor

Clinical teaching for medical undergraduates and trainees working in paediatrics

• Articles

  • Jackson RM, Hatton CF, Spegarova JS, Georgiou M, Collin J, Stephenson E, Verdon B, Haq IJ, Hussain R, Coxhead JM, Mudhar H-S, Wagner B, Hasoon M, Davey T, Rooney P, Khan A, Ward C, Brodlie M, Haniffa M, Hambleton S, Armstrong L, Figueiredo F, Queen R, Duncan CJ, Lako M. Conjunctival epithelial cells resist productive SARS-CoV-2 infection. Stem Cell Reports 2022, 17(7), 1699-1713.
  • Zainal Abidin N, Gardner AI, Robinson H, Haq IJ, Thomas MF, Brodlie M. Trends in nontuberculous mycobacteria infection in children and young people with cystic fibrosis. Journal of Cystic Fibrosis 2021, 20(5), 737-741.
  • Gardner AI, Wu Y, Verhaegh R, Liu Y, Wilker B, Soddemann M, Keitsch S, Edwards MJ, Haq IJ, Kamler M, Becker KA, Brodlie M, Gulbins E. Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis. Journal of Biological Chemistry 2021, 296, 100650.
  • Hatton CF, Botting RA, Duenas ME, Haq IJ, Verdon B, Thompson BJ, Spegarova JS, Gothe F, Stephenson E, Gardner AI, Murphy S, Scott J, Garnett JP, Carrie S, Powell J, Khan CMA, Huang L, Hussain R, Coxhead J, Davey T, Simpson AJ, Haniffa M, Hambleton S, Brodlie M, Ward C, Trost M, Reynolds G, Duncan CJA. Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2. Nature Communications 2021, 12(1), 7092.
  • Shteinberg M, Haq IJ, Polineni D, Davies JC. Cystic fibrosis. The Lancet 2021, 397(10290), 2195-2211.
  • Bain R, Cosgriff R, Zampoli M, Elbert A, Burgel P-R, Carr SB, Castaños C, Colombo C, Corvol H, Faro A, Goss CH, Gutierrez Hl, Jung A, Kashirskaya N, Marshall BC, Melo J, Mondejar-Lopez P, de Monestrol I, Naehrlich L, Padoan R, Pastor-Vivero MDl, Rizvi S, Salvatore M, Ferreira da Silva Filho L, Brownlee KG, Haq IJ, Brodlie M. Clinical characteristics of SARS-CoV-2 infection in children with cystic fibrosis: An international observational study. Journal of Cystic Fibrosis 2021.
  • Haq IJ, Althaus M, Gardner AI, Yeoh HY, Joshi U, Saint-Criq V, Verdon B, Townshend J, O'Brien C, Ben-Hamida M, Thomas M, Bourke S, van der Sluijs P, Braakman I, Ward C, Gray MA, Brodlie M. Clinical and molecular characterization of the R751L-CFTR mutation. American Journal of Physiology Lung Cellular and Molecular Physiology 2021.
  • Gardner AI, Haq IJ, Simpson AJ, Becker KA, Gallagher J, Saint-Criq V, Verdon B, Mavin E, Trigg A, Gray MA, Koulman A, McDonnell MJ, Fisher AJ, Kramer EL, Clancy JP, Ward C, Schuchman EH, Gulbins E, Brodlie M. Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine 2020, 202(8), 1133-1145.
  • Saint-Criq V, Haq IJ, Gardner AI, Garnett JP, Ward C, Brodlie M, Gray MA. Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells. Journal of Visualized Experiements 2019, (148), e59815.
  • Haq IJ, Battersby AC, Eastham K, McKean M. Community acquired pneumonia in children. BMJ 2017, 356, j686.
  • Ibrahim SH, Turner MJ, Saint-Criq V, Garnett J, Haq IJ, Brodlie M, Ward C, Borgo C, Salvi M, Venerando A, Gray MA. CK2 is a key regulator of SLC₄A2- mediated Cl-/HCO₃- exchange in human airway epithelia. Pflügers Archiv - European Journal of Physiology 2017, 469(9), 1073-1091.
  • Zainal Abidin N, Haq IJ, Gardner AI, Brodlie M. Ataluren in cystic fibrosis: development, clinical studies and where are we now?. Expert Opinion on Pharmacotherapy 2017, 18(13), 1363-1371.
  • Haq IJ, Gray MA, Garnett JP, Ward C, Brodlie M. Airway surface liquid homeostasis in cystic fibrosis: pathophysiology and therapeutic targets. Thorax 2016, 71(3), 284-287.
  • Brodlie M, Haq IJ, Roberts K, Elborn JS. Targeted therapies to improve CFTR function in cystic fibrosis. Genome Medicine 2015, 7(1), 101.
  • Haq I, Gopalakaje S, Fenton AC, McKean MC, O'Brien C, Brodlie M. The evidence for high flow nasal cannula devices in infants. Paediatric Respiratory Reviews 2014, 15(2), 124-134.
  • Haq IJ, Steinberg LJ, Hoenig M, van der Burg M, Villa A, Cant AJ, Middleton PG, Gennery AR. GvHD-associated cytokine polymorphisms do not associate with Omenn syndrome rather than T-B- SCID in patients with defects in RAG genes. Clinical Immunology 2007, 124(2), 165-169.

• Editorial

  • Haq IJ, Gardner A, Brodlie M. A multifunctional bispecific antibody against Pseudomonas aeruginosa as a potential therapeutic strategy. Annals of Translational Medicine 2016, 4(1), 12.

• Reviews

  • Haq I, Almulhem M, Soars S, Poulton D, Brodlie M. Precision Medicine Based on CFTR Genotype for People with Cystic Fibrosis. Pharmacogenomics and Personalized Medicine 2022, 15, 91-104.
  • Haq IJ, Parameswaran MC, Abidin NZ, Socas A, Gonzalez-Ciscar A, Gardner AI, Brodlie M. Modulator therapies for cystic fibrosis. Paediatrics and Child Health 2019, 29(4), 151-157.