Staff Profile

Roles:

Theme Lead: Vascular Biology and Medicine Theme 

ECR Liaison: Regenerative Medicine, Stem Cells, Transplantation Theme 

Projects Grant Committee: British Heart Foundation

Committee Member: Newcastle University Stephenson Bursary

Memberships

Leadership Team: RESETageing

Leadership Team: Healthy Aging Alliance

Collaborator: British Heart Foundation Regenerative Medicine Centres

Member: MRC Ageing Research Translation (ART) of Healthy Ageing network

Member: MRC-funded Extracellular Matrix Ageing (ECMage) Network

Editorial Positions

Editorial Board: Stem Cells

Review Editor: Frontiers in Cardiovascular Medicine

Review Editor Frontiers in Aging

Area of Expertise: Cardiac ageing, myocardial senescence, mitochondrial dysfunction, inflammation and age-related cardiovascular disease.

Professor Gavin Richardson is Lead of the Vascular Medicine and Biology Theme in the Biosciences Institute at Newcastle University. He obtained his PhD from Newcastle University in 2004, studying prostate cancer stem cell biology, before undertaking postdoctoral research at Durham University focused on dermal stem cells, tissue regeneration and skin ageing. In 2010, he returned to Newcastle University on an independent fellowship to apply his expertise in stem cell biology, regeneration and ageing to the study of cardiovascular disease.

Professor Richardson’s research focuses on understanding how cellular senescence contributes to myocardial ageing, inflammation, fibrosis and maladaptive cardiac remodelling. His work combines human cardiac tissue analysis, single nuclei RNA sequencing, spatial transcriptomics, in vitro cardiomyocyte models and preclinical intervention studies to define the cellular and molecular signatures of cardiac senescence. His current research seeks to identify novel biomarkers of cardiac ageing and cardiovascular disease, define the mechanisms linking senescence, mitochondrial dysfunction and senescence associated inflammation, and develop new therapeutic approaches to improve myocardial health in ageing and disease.

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Orcid

Current Grants as PI

• CONNECT FTMA. Building a Cross-Institution Training and Imaging Pipeline for Near-Infrared Tracking of Senolytic Drugs. 2026-2027 £21,000
• British Heart Foundation Infrastructure Grant (IG/F/25/50016). High-resolution preclinical ultrasound imaging system for Newcastle University. £137,282.78.
• British Heart Foundation project Grant (PG/25/12397). 2025-2028: CARDIAC-MAP: cardiac mapping of ageing pathology. £345,634.00
• NIHR - National Institute for Health and Care Research. Processing of Human Skeletal Muscle Biopsies. £8,152
• British Heart Foundation project Grant (PG/25/12266). 2025-2028: CRISIS: cardiac remodelling and injury via senescent immune cells. £271,196.0
• British Heart Foundation studentship (FS/PhD/25/29642). 2025-2028: The dynamic duo: How p16 and p21 drive senescence in cardiovascular disease. £124,619.47
• HESI Thrive - Health and Environmental Sciences Institute. Enhancing mitophagy for the treatment of anthracycline. 2024-2029. £38,462
• British Heart Foundation project Grant PG/23/11571. 2024-2027: Characterising chemotherapy-induced cardiac cell senescence to ascertain its role in chemotherapy- induced heart failure. £279,661.00

Current Grants as Co-I

• BBSRC mid-range equipment. Upgrading In vivo Imaging Technology to Advance Biomedical Research at Newcastle University. 2026. £539,866.00
• Jeffcock and Luccock Endowment/JJ Hunter Bequest PhD Studentship Exploring the application of geocomputational methods to high resolution spatial transcriptomics data from the human heart. 2026-2029 £84,336
• British Heart Foundation Clinical Research Training Fellowship (FS/CRTF/23/24520) 2023-2026: Deep immunophenotyping and functional analysis of leucocytes in heart failure. £334,731.97
• British Heart Foundation project Grant PG/23/11093. 2023-2026: Role of Amyloid-beta in cardiovascular ageing. £310,248.00 
• MRC mid-sized equipment grant: MRC application: Small Animal Radiation Research Platform (SARRP). £596,653

Senescence, Regeneration and Cardiovascular Ageing

Ageing is the major risk factor for cardiovascular disease and is associated with poorer outcomes following cardiac injury, including myocardial infarction. Our research investigates why the ageing heart becomes more vulnerable to disease, with a particular focus on the loss of regenerative capacity, the accumulation of senescent cells and the inflammatory tissue environment that develops with age.

Our previous work has shown that cardiomyocyte turnover declines with age, suggesting that impaired regenerative potential may contribute to age-related cardiac dysfunction and reduced recovery after myocardial injury. Alongside this, cellular senescence increases with age. Senescent cells are characterised by a stable loss of proliferative capacity and the production of a senescence-associated secretory phenotype, or SASP, which can promote inflammation, fibrosis, hypertrophy and tissue remodelling.

Senescence and Myocardial Remodelling

We have demonstrated that cellular senescence is induced following myocardial infarction. Through the production of the SASP, senescent cells can create a local tissue environment that promotes further senescence, inflammation, fibrosis and adverse myocardial remodelling. These processes contribute to impaired cardiac function and poorer recovery after injury.

Importantly, our work and that of others has shown that targeting senescent cells can improve cardiac outcomes in preclinical models. Senolytic therapies, which selectively eliminate senescent cells, reduce senescence-associated inflammation, attenuate adverse remodelling and improve cardiac function following myocardial injury. This supports the concept that senescence is not simply a marker of cardiac ageing and disease, but a therapeutically targetable driver of myocardial dysfunction.

Current Research Focus

Our current research aims to define the cellular and molecular signatures of cardiac senescence in ageing and disease. We use human myocardial tissue, single nuclei RNA sequencing, spatial transcriptomics, in vitro cardiomyocyte models and preclinical intervention studies to understand which cardiac cell populations become senescent, how they interact with their surrounding tissue environment and how they contribute to inflammation, fibrosis and myocardial dysfunction.

A key focus is understanding the distinct roles of p16 and p21 expressing senescent cells, how these populations differ between ageing and cardiovascular disease, and whether they can be selectively targeted to improve myocardial health.

Our Goal

Our long-term goal is to develop new approaches to identify, understand and therapeutically target senescence in the ageing and diseased heart. By defining how senescent cells contribute to cardiac inflammation, fibrosis and impaired repair, we aim to develop novel biomarkers and interventions that improve cardiovascular health during ageing and enhance recovery following myocardial infarction.

PSC2020 – BSc Cardiovascular System Physiology

MMB8037 - MRes Cardiovascular Science in Health and Disease

MMB8038 - MRes Bioscience Research Development and Enterprise

• Articles

  • Mathison L, Richardson GD, Booth L, Redgrave RE, White S, Korolchuk V. The dynamic duo: how p16 and p21 drive senescence in cardiovascular disease. Heart 2026, 112(Suppl 1), A276.
  • Booth LK, Redgrave RE, Camacho-Encina M, Trevisan-Herraz M, Walker L, Ma G, Mathison L, Tual-Chalot ST, Gill J, Korolchuk V, Richardson GD. Small molecule mitophagy enhancers prevent doxorubicin-induced cardiomyocyte senescence–therapeutic potential in anthracycline-induced cardiotoxicity?. Heart 2026, 112(Suppl 1), A260-A261.
  • Villalobos E, Redgrave R, Clark J, MacGowan G, Richardson GD. Exploring biomechanical control of adipogenic features in the injured heart. Heart 2026, 112(Suppl 1), A290-A291.
  • Trevisan-Herraz M, Redgrave R, Richardson GD. Cell type resolved transcriptomics reveals senolytic driven rejuvenation of the ageing cardiac microenvironment. Heart 2026, 112(Suppl 1), A289.
  • Granic A, Simoes DSM, Bowen TS, Almaghtuf N, Richardson G, Sayer AA. Ageing of human myofibres in the Vastus Lateralis muscle: a narrative review. Ageing Research Review 2026, 115, 103022.
  • Fullerton MO, Phillips L, Redgrave R, Spray L, Haufroid V, Merces G, Kerridge ST, Richardson GD, Mercier N, Roland D, Crossley R, Morgan ADH, Dewulf JP, Burn J, Bamforth S, Phillips HM. A Slc5a6-Deficient Mouse Model Reveals Metabolically Driven Cardiomyopathy with Therapeutic Potential for Vitamin-Based Intervention. JCI Insight 2026.
  • Nascimento L, Richardson GD, Melo P, Barroca N. The hidden power of glycine: A small amino acid with huge potential for piezoelectric and piezo-triboelectric nanogenerators. Chemical Engineering Journal 2025, 510, 161514.
  • Liberale L, Tual-Chalot S, Sedej S, Ministrini S, Georgiopoulos G, Grunewald M, Bäck M, Bochaton-Piallat M, Boon R, Ramos G, de Winther M, Drosatos K, Evans P, Ferguson J, Forslund-Startceva S, Goettsch C, Giacca M, Haendeler J, Kallikourdis M, Ketelhuth D, Koenen R, Lacolley P, Lutgens E, Maffia P, Miwa S, Monaco C, Montecucco F, Norata G, Osto E, Richardson GD, Riksen N, Soehnlein O, Spyridopoulos I, Van Linthout S, Vilahur G, Wentzel J, Andrés V, Badimon L, Benetos A, Binder C, Brandes R, Crea F, Furman D, Gorbunova V, Guzik T, Hill J, Lüscher T, Mittelbrunn M, Nencioni A, Netea M, Passos J, Stamatelopoulos K, Tavernarakis N, Ungvari Z, Wu J, Kirkland J, Camici G, Dimmeler S, Kroemer G, Abdellatif M, Stellos K. Roadmap for alleviating the manifestations of ageing in the cardiovascular system. nature reviews cardiology 2025, 22, 577–605.
  • Redgrave R, Walaszczyk A, Dewi MW, Encina MC, Clemens J, Matrins R, Richardson GD, Das M. The effect of varying irrigation flow-rate during irrigated radiofrequency ablation on optimising lesion shape. EP Europace 2024, 26(1), euad321.
  • Kelly G, Kataura T, Panek J, Gailing M, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI. Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule. Developmental Cell 2024, 59(15), 1924-1939.e7.
  • Tomkova K, Roman M, Adebayo AS, Sheikh S, Yusoff S, Gulston M, Joel-David L, Lai FY, Murgia A, Eagle-Hemming B, Aujla H, Chad T, Richardson GD, Griffin JL, Murphy GJ, Wozniak MJ. Multimorbidity is associated with myocardial DNA damage, nucleolar stress, dysregulated energy metabolism, and senescence in cardiovascular disease. npj Aging 2024, 10, 58.
  • Camacho-Encina M, Booth LK, Redgrave R, Honkanen-Scott MM, Scott III WE, Martin-Ruiz C, MacGowan G, Richardson S, Dark J, Tual-Chalot S, Richardson GD. Identifying optimal reference genes for real-time quantitative polymerase chain reaction in human myocardial tissues. Cardiovascular Research 2024, 120(17), 2163-2165.
  • Nguyen H, Hsu C, Meeson A, Oldershaw RA, Richardson GD, Czosseck A, Lundy D. Differentiation, metabolism and cardioprotective secretory functions of human cardiac stromal cells from ischemic and endocarditis patients. Stem Cells and Development 2024, 33(17-18), 484-495.
  • Camacho-Encina M, Booth LK, Redgrave RE, Folaranmi O, Spyridopoulos I, Richardson DG. Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease. Cells 2024, 13(4), 353.
  • Ekinci Y, Richardson GD, Spyridopoulos I. A Phase IIa Clinical Trial of KAND567, Fractalkine Receptor Inhibitor, in Patients with ST-Elevation Acute Myocardial Infarction after Percutaneous Coronary Intervention. Journal of Pharmacology and Experimental Therapeutics 2024, 389(S3), 472.
  • Booth L, Redgrave R, Camacho Encina M, Tual-Chalot S, Folaranmi O, Martin-Ruiz C, Spyridopoulos I, Gill J, Richardson GD. The senescence-associated secretory phenotype as a biomarker for age-related myocardial remodelling and cardiovascular disease. Heart 2023, 109(Supp. 3), A265-A266.
  • Redgrave R, Dookun E, Booth LK, Camacho Encina M, Folaranmi O, Tual-Chalot S, Gill JH, Owens WA, Spyridopoulos I, Passos JF, Richardson GD. Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction. npj Aging 2023, 9, 15.
  • Witham MD, Granic A, Miwa S, Passos JF, Richardson GD, Sayer AA. New Horizons in cellular senescence for clinicians. Age and Ageing 2023, 52(7), afad127.
  • Camacho Encina M, Tyler A, Hardwick I, Booth L, Redgrave R, Richardson GD. Identifying older donor hearts suitable for transplantation: the use of senescence as a marker of biological age. Heart 2023, 109(Supp. 3), A288-A289.
  • Loh SX, Ekinci Y, Spray L, Jeyalan V, Olin T, Richardson G, Austin D, Alkhalil M, Spyridopoulos I. Fractalkine Signalling (CX₃CL1/CX₃CR1 Axis) as an Emerging Target in Coronary Artery Disease. J. Clin. Med 2023, 12(14), 4821.
  • Kateryna, Tual-Chalot S, Mueller-Hennessen M, Vlachogiannis N, Georgiopoulos G, Biener M, Sachse M, Turchinovich A, Polycarpou-Schwarz M, Spray L, Maneta E, Bennaceur K, Mohammad A, Richardson GD, Gatsiou A, Langer HF, Frey N, Stamatelopoulos K, Heineke J, Duerschmied D, Giannitsis E, Spyridopoulos I, Stellos K. Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction. Frontiers in Immunology 2023, 14, 1177467.
  • Tomkova k, Roman M, Adebayo AS, Sheikh S, Yusoff S, Gulston M, Joel-David L, Lai FY, Murgia A, Eagle-Hemming B, Aujla H, Richardson GD, Griffin JL, Murphy GJ, Wozniak MJ. DNA damage, nucleolar stress and dysregulated energy metabolism as mechanisms of multimorbidity. medRxiv 2023, 2023.02.22.23286318.
  • Bawamia B, Spray L, Wangsaputra VK, Bennaceur K, Vahabi S, Stellos K, Kharatikoopaei E, Ogundimu E, Gale CP, Keavney B, Maier R, Hancock H, Richardson GD, Austin D, Spyridopoulos I. Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction Randomized Pilot Trial. GeroScience 2023, 45, 2689-2705.
  • Dookun E, Passos JF, Arthur HM, Richardson GD. Therapeutic Potential of Senolytics in Cardiovascular Disease. Cardiovascular Drugs and Therapy 2022, 36, 187-196.
  • Oldershaw RA, Richardson GD, Carling P, Owens WA, Lundy DJ, Meeson A. Cardiac Mesenchymal Stem Cell-like Cells Derived from a Young Patient with Bicuspid Aortic Valve Disease Have a Prematurely Aged Phenotype. Biomedicines 2022, 10(12), 3143.
  • Spray L, Park C, Cormack S, Mohammed A, Panahi P, Boag S, Bennaceur K, Sopova K, Richardson G, Stangl V, Rech L, Rainer P, Ramos G, Hofmann U, Stellos K, Spyridopoulos I. The Fractalkine Receptor CX3CR1 Links Lymphocyte Kinetics in CMV-Seropositive Patients and Acute Myocardial Infarction With Adverse Left Ventricular Remodeling. Frontiers in Immunology 2021, 12, 605857.
  • Coelho-Lima J, Georgiopoulos G, Ahmed J, Adil Syeda, Gaskin D, Bakogiannis C, Sopova k, Ahmed F, Ahmed H, Spray L, Richardson G, Bagnall A, Stellos K, Stamatelopoulos K, Spyridopoulos I. Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction. Heart BMJ 2021, 107(23), 1881-1888.
  • Spray L, Park C, Cormack S, Mohammad A, Panahi P, Boag S, Bennaceur K, Richardson G, Arthur H, Stellos K, Spyridopoulos I. Role of CMV-serostatus and CX3CR1 on lymphocyte kinetics and left ventricular remodelling in patients with acute myocardial infarction. European Heart Journal 2020, 41(Suppl. 2), ehaa946.1289.
  • Liu D, Richardson G, Benli FM, Park C, de Souza JV, Bronowska AK, Spyridopoulos I. Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies. Clinical Science 2020, 134(17), 2243-2262.
  • Martin-Ruiz C, Hoffmann J, Shmeleva E, von Zglinicki T, Richardson G, Draganova L, Redgrave R, Collerton J, Arthur H, Keavney B, Spyridopoulos I. CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians. npj Aging and Mechanisms of Disease 2020, 6, 3.
  • Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep O, Santin Y, Mialet Perez J, Owens WA, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery. Aging Cell 2020, 19(10), e13249.
  • CorreiaMelo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk V, Passos JF. Rapamycin improves healthspan but not inflammaging in nfkb1-/- mice. Aging Cell 2019, 18(1), e12882.
  • Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot A, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD. Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction. Aging Cell 2019, 18(3), e12945.
  • Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens WA, Greaves L, Kolsky K, Parini A, Douin-Echinard V, LeBrasseur N, Arthur H, Tual-Chalot S, Schafer M, Roos C, Miller J, Robertson N, Mann J, Adams P, Tchkonia T, Kirkland J, Mialet-Perez J, Richardson GD, Passos J. Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence. The EMBO Journal 2019, 38(5), e100492.
  • Oldershaw R, Owens WA, Sutherland R, Linney M, Liddle R, Magana L, Lash GE, Gill JH, Richardson G, Meeson A. Human Cardiac-Mesenchymal Stem Cell-Like Cells, a Novel Cell Population with Therapeutic Potential. Stem Cells and Development 2019, 28(9), 593-607.
  • Richardson G, Sage A, Bennaceur K, Al Zhrany N, Coelho-Lima J, Dookun E, Draganova L, Saretzki G, Breault D, Mallat Z, Spyridopoulos I. Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2018, 38(6), 1283-1296.
  • Anderson R, Richardson GD, Passos JF. Mechanisms driving the ageing heart. Experimental Gerontology 2018, 109, 5-15.
  • Richardson GD. Simultaneous Assessment of Cardiomyocyte DNA Synthesis and Ploidy: A Method to Assist Quantification of Cardiomyocyte Regeneration and Turnover. Journal of Visualized Experiments 2016, (111), e53979.
  • Madich A, Richardson GD, Jahoda CAB. Contribution of GFP expressing Dermal Papillae cells to the formation of chimeric embryos and their survival in uterine environment. British Biotechnological Journal 2016, 12(2), 23393.
  • Richardson GD, Laval S, Owens WA. Cardiomyocyte regeneration in the mdx mouse model of non-ischemic cardiomyopathy. Stem Cells and Development 2015, 24(14), 1672-1679.
  • Bennaceur K, Atwill M, Al Zhrany N, Hoffmann J, Keavney B, Breault D, Richardson G, von Zglinicki T, Saretzki G, Spyridopoulos I. Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism. Atherosclerosis 2014, 236(2), 312-320.
  • Meeson A, Fuller A, Breault D, Owens W, Richardson G. Optimised Protocols for the Identification of the Murine Cardiac Side Population. Stem Cell Reviews and Reports 2013, 9(5), 731-739.
  • Richardson GD, Breault D, Horrocks G, Cormack S, Hole H, Owens WA. Telomerase expression in the mammalian heart. FASEB Journal 2012, 26(12), 4832-4840.
  • Richardson GD, Meeson A, Laval S, Fuller A, Owens A. mTERT EXPRESSION IS INCREASED IN THE MDX MODEL OF CARDIOMYOPATHY. Heart 2012, 98:A8.
  • Bell E, Richardson G, Jahoda CA, Gledhill K, Phillips HM, Henderson D, Owens WA, Hole N. Dermal stem cells can differentiate down an endothelial lineage. Stem Cells and Development 2012, 21(16), 3019-3030.
  • Meeson A, Owens WA, Richardson GD. Analysis of the Murine Cardiac Side Population from Postnatal to Adult heart; The Effect of Aging.. 2012.
  • Higgins CA, Richardson GD, Ferdinando D, Westgate GE, Jahoda CA. Modelling the hair follicle dermal papilla using spheroid cell cultures. Experimental Dermatology 2010, 19(6), 546-548.
  • Richardson GD, Bazzi H, Fantauzzo KA, Waters JM, Crawford H, Hynd P, Christiano AM, Jahoda CA. KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development 2009, 136(13), 2153-2164.
  • Higgins CA, Richardson GD, Westgate GE, Jahoda CA. Exogen involves gradual release of the hair club fibre in the vibrissa follicle model. Experimental Dermatology 2009, 18(9), 793-795.
  • Waters J, Richardson G, Dhouailly D, Jahoda C. Epithelial–mesenchymal interactions promote hair follicle neogenesis and a new stem cell niche in adult corneal epithelium. MECHANISMS OF DEVELOPMENT 2009, 126, S151 – S181.
  • Richardson GD, Fantauzzo KA, Bazzi H, Määttä A, Jahoda CA. Dynamic expression of Syndecan-1 during hair follicle morphogenesis. Gene Expression Patterns 2009, 9(6), 454-460.
  • Bazzi H, Fantauzzo KA, Richardson GD, Jahoda CA, Christiano AM. Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression. Developmental Dynamics 2007, 236(4), 961-970.
  • Bazzi H, Fantauzzo KA, Richardson GD, Jahoda CA, Christiano AM. The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis. Developmental Biology 2007, 305(2), 498-507.
  • Richardson GD, Arnott EC, Whitehouse CJ, Lawrence CM, Hole N, Jahoda CAB. Cultured cells from the adult human hair follicle dermis can be directed toward adipogenic and osteogenic differentiation. Journal of Investigative Dermatology 2005, 124(5), 1090-1091.
  • Richardson GD, Robson CN, Lang S, Neal DE, Maitland N, Collins AT. CD133, a novel marker for human prostatic epithelial stem cells. Journal of Cell Science 2004, 117(16), 3539-3545.

• Book Chapter

  • Booth k, Redgrave R, Tual-Chalot s, Spyridopoulos I, Phillips HM, Richardson GD. Heart Disease and Ageing: The Roles of Senescence, Mitochondria, and Telomerase in Cardiovascular Disease. In: Harris, J.R., Korolchuk, V.I, ed. Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science. Cham, Switzerland: Springer, 2023, pp.45-78.

• Conference Proceedings (inc. Abstracts)

  • Walaszczyk A, Dookun E, Redgrave R, Palmowski P, Tual Chalot S, Gill E, Owens A, Grieve D, Spyridopoulos I, Taggart M, Arthur H, Passos J, Richardson GD. Therapeutic potential of navitoclax in age-related cardiovascular diseases. In: Termis 6th World Congress. 2022, Maastricht, Netherlands: Mary Ann Liebert.
  • Spyridopoulos I, Bawamia B, Spray L, Wangsaputra V, Stellos K, Bennaceur K, Kharatikoopaei E, Ogundimu E, Gale CP, Keavney B, Maier R, Hancock H, Richardson G, Austin D. Activation of mitochondrial telomerase reverses relative lymphopenia post myocardial infarction: results from the randomised, double-blinded TACTIC phase IIa pilot trial. In: ESC Congress 2022. 2022, Barcelona, Spain: Oxford University Press.
  • Yausep Oliver, Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. The Effects of Senolytics on Murine Cardiac Function and Morphology Post-Ischemia Reperfusion Injury. In: 24th ASEAN Federation Cardiology Congress (24th AFCC) 28th Annual Scientific Meeting of the Idonesian Heart Association (28th ASMIHA). 2019, Faculty of Medicine, University of Indonesia, Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia.
  • Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. Navitoclax eliminates senescence attenuating remodelling and improving outcome to cardiac ischemia-reperfusion injury. In: Senescence Symposium. 2019, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, UK.
  • Doyle j, Dyson N, Bourne M, Honkanen-Scott M, Hunter H, Jones C, Coulthard R, Ness T, Bury Y, Tiniakos D, Fisher AJ, Dark J, Richardson GD, Scott WE, Ploeg RJ, Shaw JAM. MRC-QUOD Expand: Creation of Searchable Organ Pathology Atlases. In: Molecular Pathology: Innovation for a Digital Future. 2019. In Preparation.
  • Dewi M, Walaszczyk A, Das M, Richardson G. Continuous Reduction In Irrigation Rate During Irrigated Radiofrequency Catheter Ablation Results In A More Optimised Lesion Shape Through Reduced Endocardial Sparing. In: Heart Rhythm Congress (HRC) 2019. 2019, International Convention Centre (ICC), Birmingham: Touch Medical Media Ltd.
  • Walaszczyk A, Dookun E, Redgrave R, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. Senescence contributes to reduced survival and impaired cardiac function following myocardial infraction in aged mice. In: 9th Annual Alliance for Healthy Aging Conference. 2018, Mayo Clinic Rochester, MN, USA.
  • Walaszczyk A, Dookun E, Redgrave R, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. Senescence contributes age related cardiac dysfunction. In: 26th Northern Cardiovascular Research Group Meeting. 2018, Newcastle, UK.
  • Walaszczyk A, Dookun ER, Redgrave R, Tual-Chalot S, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson GD. Senescence as a therapeutic target for myocardial ageing. In: BAS/BSCR Spring Meeting 2018. 2018, Manchester, UK: Heart.
  • Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. Cardiomyocyte Senescence accumulates following Myocardial Infarction and Ischaemia-Reperfusion Injury. In: 26th Northern Cardiovascular Research Group Meeting. 2018, Newcastle upon Tyne.
  • Dookun ER, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson GD. Accumulation of cardiomyocyte senescence following ischaemia-reperfusion injury (IRI); a potential therapeutic target?. In: BAS/BSCR Spring Meeting 2018. 2018, Manchester, UK: Heart.
  • Anderson R, TualChalot S, Redgrave R, Dodds R, Owens WA, Saretzki G, Arthur H, vonZglinicki T, Passos JF, Richardson GD. The role of cardiomyocyte senescence and regeneration in Ageing. In: British Microcirculation Society 66th Annual Meeting. 2016, Newcastle upon Tyne, UK: BMS.
  • Rockley KL, Richardson GD, Gill JH. Characterisation of novel molecular mechanisms involved in anthracycline-induced cardiotoxicity. In: British Toxicology Society Annual Congress 2016. 2016.
  • Owens WA, Richardson GD. Cardiomyocyte regeneration in non-ischaemic cardiomyopathy. In: Weinstein Cardiovascular Conference. 2014, Madrid, Spain.
  • Meeson AP, Laval SH, Owens WA, Richardson GD. The Cardiac Side Population is Dynamic during the Progression of Cardiomyopathy in the mdx Model of DMD. In: EMBO/EMBL: Cardiac Biology - From Development to Regenerative Medicine. 2013, Heidelberg, Germany.
  • Richardson G, Meeson A, Fuller A, Owens A. The Cardiac Side Population is Dynamic during the Progression of Cardiomyopathy in the mdx Model of DMD. In: EMBO/EMBL: Cardiac Biology - From Development to Regenerative Medicine. 2013, Heidelberg, Germany.
  • Richardson GD, Meeson AP, Laval SH, Fuller A, Owens WA. mTert Expression is Increased in the MDX Model of Cardiomyopathy. In: BSCR Autumn Meeting. 2012, Belfast, Ireland: BMJ Publishing Group.
  • Richardson GD, Meeson AP, Laval SH, Fuller A, Owens WA. mTert Expression is Increased in the mdx Model of Cardiomyopathy. In: BSCR. Novel Insights into the Pathogenesis of Cardiac Remodelling. 2012, Queens University Belfast.
  • Richardson GD, Breault D, Horrocks G, Cormack S, Hole N, Owens WA. The Identification of Native Cardiac Stem Cells Based on Telomerase Activity. In: CNIC: Centro Nacional de Investigaciones Cardiovasculares. 2010, Madrid, Spain.
  • Wojciechowicz K, Richardson G, Waters J, Markiewicz E, Higgins C, Christiano A, Jahoda C. Molecular characterization of perifollicular adipogenesis during mouse skin development Free Papers. In: 6th World Congress for Hair Research. 2010, Cairns, Australia.
  • Higgins C, Itoh I, Inoue K, Richardson G, Jahoda C, Christiano A. Generation of induced pluripotent stem cells by reprogramming human dermal papilla cells Stem Cells, Stem Cell Niches and Cicatricial Alopecia. In: 6th World Congress for Hair Research. Cairns. 2010, Cairns, Australia.
  • Richardson GD, Jahoda C. Multiple Properties of Hair Follicle Dermis Include Stem Cell Potential, Stem Cell Support, and Epithelial Reprogramming. In: Bionet. 2009, Korea.
  • Chen B, Crawford H, Fearn A, Harris S, Liu J, Richardson GD, Waters JM, Reynolds AJ, Whitehouse J, Wojciechowicz K, Jahoda CAB. Stem and developmental potential of the hair follicle – induction, regeneration, wound healing and stem cells. In: Anatomical society of Great Britain and Northern Ireland Summer Meeting in association with the North East Stem Cell Institute (NESCI). 2007, Durham, UK.
  • Waters JM, Richardson GD, Fearn A, Taghizadeh R, Dhouailly D, Jahoda CAB. Hair and skin differentiation from the transit amplifying cells of the central cornea. In: 5th Annual International Society for Stem Cell Research Annual Meeting. 2007, Cairns, Queensland, Australia.
  • Richardson GD, Bazzi H, Fantauzzo KA, Waters JM, Crawford H, Hynd P, Christiano AM, Jahoda CA. Activation of EGF and FGF signaling in developing mouse skin inhibits hair follicle morphogenesis. In: Fifth International Congress on Hair Research. 2007, Vancouver, British Colombia, Canada.
  • Richardson GD, Jahoda C. Determining the molecular basis of hair follicle induction. In: 12th Annual Meeting of the European Hair Research Society (EHRS). 2006, London, UK.
  • Richardson GD, Arnott EC, Whitehouse CJ, Lawrence CM, Reynolds AJ, Hole N, Jahoda CAB. Plasticity of rodent and human hair follicle dermal cells: Implications for cell therapy and tissue engineering. In: Journal of Investigative Dermatology Symposium Proceedings: 4th International Meeting of Hair Research Societies. 2005, Berlin, Germany: Nature Publishing Group.
  • Richardson GD, Bazzi H, Fantauzzo KA, Waters JM, Crawford H, Hynd P, Christiano AM, Jahoda CA. Analysing the mechanisms of follicle dermal cell aggregation and induction: a cell and molecular study. In: Epithelial Differentiation & Keratinization. 2005, Lucca, Italy.
  • Richardson GD, Arnott EC, Whitehouse CJ, Lawrence CM, Reynolds AJ, Hole N, Jahoda CA. Stem cell potential of adult hair follicle dermal cells. In: 4th Intercontinental Meeting of Hair Research Societies. 2004, Berlin, Germany.
  • Richardson GD, Robson CN, Lang SH, Neal DE, Maitland NJ, Collins AT. CD133 as a putative prostatic epithelial stem cell marker. In: Northern England & Scottish Urologist Society Special meeting. 2003.
  • Richardson GD, Robson CN, Lang SH, Neal DE, Maitland NJ, Collins AT. Identification of differentially-expressed genes in the stem cells and transit amplifying compartments of prostatic epithelia by microarray. In: The British Prostate Group Collaborative Executive Meeting. 2002.
  • Richardson GD, Robson CN, Lang SH, Neal DE, Maitland NJ, Collins AT. CD133 as a putative prostatic epithelial stem cell marker. In: The British Prostate Group Collaborative Executive Meeting. 2002.
  • Richardson GD, Robson CN, Collins AT. AC133 as a putative prostatic epithelial stem cell marker. In: The British Prostate Group Annual Meeting. 2001.

• Letters

  • Higgins CA, Itoh M, Inoue K, Richardson GD, Jahoda CA, Christiano AM. Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells. Journal of Investigative Dermatology 2012, 132, 1725-1727.
  • Waters JM, Richardson GD, Jahoda CA. Keratin 10 (K10) is expressed suprabasally throughout the limbus of embryonic and neonatal rat corneas, with interrupted expression in the adult limbus. Experimental Eye Research 2009, 89(3), 435-438.

• Research Dataset/Database

  • Anderson R, Maggiorani D, Robertson NA, Mialet-Perez J, Richardson GD, Passos JF. Young vs Old mouse cardiomyocytes RNA-Seq. 2018. Gene expression omnibus: NCBI.

• Reviews

  • Spray L, Richardson GD, Booth LK, Haendeler J, Altschmied J, Bromage DI, Wallis SB, Stellos K, Tual-Chalot S, Spyridopoulos I. How to measure and model cardiovascular aging. Cardiovascular Research 2025, 121(10), 1489-1508.
  • Redgrave RE, Booth LK, Richardson GD. From immunosenescence to diastolic dysfunction: tracing the senescence cascade in heart failure with preserved ejection fraction. Cardiovascular Research 2025, 121(15), 2288–2290.
  • Spray L, Richardson G, Haendeler J, Altschmied J, Rumampouw V, Wallis SB, Georgiopoulos G, White S, Unsworth A, Stellos K, Tual-Chalot S, Spyridopoulos I. Cardiovascular inflammaging: Mechanisms, consequences, and therapeutic perspectives. Cell Reports Medicine 2025, 6(9), 102264.
  • Booth LK, Redgrave RE, Folaranmi O, Gil JH, Richardson GD. Anthracycline-induced cardiotoxicity and senescence. Frontiers in Aging 2022, 3, 1058435.
  • Hoffmann J, Richardson GD, Haendeler J, Altschmied J, Andrés V, Spyridopoulos I. Telomerase As a Therapeutic Target in Cardiovascular Disease. Arteriosclerosis, Thrombosis, and Vascular Biology 2021, 41(3), 855-865.
  • Owens WA, Walaszczyk A, Spyridopoulos I, Dookun E, Richardson GD. Senescence and Senolytics in Cardiovascular disease: Promise and Potential Pitfalls. Mechanisms of Ageing and Development 2021, 198, 111540.
  • Waters JM, Richardson GD, Jahoda CA. Hair follicle stem cells. Seminars in Cell & Developmental Biology 2007, 18(2), 245-254.